1st Order derivative spectrophotometer determination of sertraline in pharmaceutical tablets by p-chloranilic acid

Abstract EN

Rapid, accurate and sensitive method has been developed and validated for the determination of Sertraline in pharmaceutical tablets; the present method is based on First Order derivative spectrophotometry of the colored product which was formed by charge transfer complication of sertraline (n-donor) with π-acceptor chloranilic acid.

First derivative spectrophotometry has been evaluated by measuring of the derivative signal at475.72 nm–588.40 nm (peak to peak amplitude).

Calibration graph was established for 5-100 μg.mL-1 of sertraline with main percentage recoveries.

The proposed method was applied successfully to the determination of sertraline in pharmaceutical tablet with good accuracy and precision.