Synthesis and characterization of some new pentadienoic acid derivatives

Abstract EN

Phytochemical investigation of the stem bark of Azadirachta indica resulted in the isolation of an acyclic norditerpene 2, 6, 10, 14-tetra methyl pentadeca-8-en-2,7β-diol (azadirechterpinol A) (1), a monocyclic homoditerpene 2, 6, 10-trim ethyl-l4-cyclopent-15-enyl-o-tetrad can-6α, 8α- diol (azadirterpinol B) (2), a sterol glycoside stigmast-5, 7-dien-3 β-ol-β-D-glucopyranoside (3) and an acyclic norsesquiterpenic acid 9, 9-dimethyl decan-7-en-2-o1-11,12-dioic acid (azadirachtoic acid) (4), along with the aliphatic constituents 6-methyl-n-triacontane (5), n-heptacosan-8β-ol (6) and n-hexacosanoic acid (7).

The structures of all these phytoconstituents have been illustrated on the basis of spectral data analyses and chemical reactions.