Antinociceptive effect of two flavonoids from aloysia triphylla l.

Abstract EN

Aloysius triphylla, known in Jordan as Melisa, is a plant that belongs to the Verbenaceae.

This plant has been used in herbal medicine as sedative agent and helps to counter depression.

Phytochemical analysis of the ground aerial parts of Aloysius triphylla resulted in the isolation of two known compounds: arteritis and hesperidin.

The two compounds were assessed for ant nociceptive activities in mice, using the classical in vivo model of pain, the hot plate test.

Artemisia and hesperidin (given i.p.) increased significantly (P < 0.05) the pain latency of nociceptive response in dose dependent manner.

The ED50 values were 1.6 x10-3 mg / kg for arteritis (n = 6) and 3.2 x 10-1 mg / kg for hesperidin (n = 6).

The present data indicate that the two flavonoids (arteritis and hesperidin) possess significant ant nociceptive effects in mice which seem to justify the traditional analgesic use of Aloysius triphylla.