Antihyperglycemic and antihyperlipidaemic activities of root extracts of calotropis procera (ait.) r.br on streptozotocin induced diabetic rats
Joint Authors
Bhaskar, V. H.
Ajay, Sumant Singh
Source
Jordan Journal of Biological Sciences
Issue
Vol. 2, Issue 4 (31 Dec. 2009), pp.177-180, 4 p.
Publisher
The Hashemite University Deanship of Academic Research and Graduate
Publication Date
2009-12-31
Country of Publication
Jordan
No. of Pages
4
Main Subjects
Topics
Abstract EN
The root extracts of Caltrops procure were investigated for its anti-hyperglycemic effect in Male Wister Albino rats.
Diabetes was induced by administration of single dose of streptozotocin (STZ, 50 mg / kg, I.P) Pet.
ether, methanol and aqueous extracts of roots of C.
procure at dose of 250 mg / kg, b.
w t were administered as a single dose, per day to diabetes rats for the period of 15 days, respectively.
After extracts treatment, the blood glucose levels were decreased from 238.6 ± 2.30 to 198.8 ± 1.8 and 236.0 ± 1.58 to 154.0 ± 1.58, 236.0±1.58 to 142.6 ± 2.07 and 238.6±2-64 to 164.4±2.70 mg / dL respectively.
The effect of C.
procure on blood glucose level was measured in the diabetic rats.
Serum lipid profile like total cholesterol (TC), triglycerides (TG), phospholipids (PL), low density lipoprotein (LDL), very low density lipoprotein (VLDL) and high density lipoprotein (HDL) were measured in the diabetic rats.
The activities were also compared to that effect produced by a standard anti-diabetic agent, glibenclamide 500μg / kg.
The present investigation established pharmacological evidence to support the folklore claim that it is an anti-diabetic agent.
American Psychological Association (APA)
Bhaskar, V. H.& Ajay, Sumant Singh. 2009. Antihyperglycemic and antihyperlipidaemic activities of root extracts of calotropis procera (ait.) r.br on streptozotocin induced diabetic rats. Jordan Journal of Biological Sciences،Vol. 2, no. 4, pp.177-180.
https://search.emarefa.net/detail/BIM-266966
Modern Language Association (MLA)
Bhaskar, V. H.& Ajay, Sumant Singh. Antihyperglycemic and antihyperlipidaemic activities of root extracts of calotropis procera (ait.) r.br on streptozotocin induced diabetic rats. Jordan Journal of Biological Sciences Vol. 2, no. 4 (Dec. 2009), pp.177-180.
https://search.emarefa.net/detail/BIM-266966
American Medical Association (AMA)
Bhaskar, V. H.& Ajay, Sumant Singh. Antihyperglycemic and antihyperlipidaemic activities of root extracts of calotropis procera (ait.) r.br on streptozotocin induced diabetic rats. Jordan Journal of Biological Sciences. 2009. Vol. 2, no. 4, pp.177-180.
https://search.emarefa.net/detail/BIM-266966
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 179-180
Record ID
BIM-266966