Antibody-mediated rejection : importance of lactate dehydrogenase and neutrophilia in early diagnosis
Joint Authors
Abd al-Halim
Khan, Taqi Toufeeq
Mirza, Anzar Baig
Zahid, Rafat
al-Husayni, Hassah
Mousa, Dujana
al-Sulayman, Muhammad H.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 22, Issue 3 (30 Jun. 2011), pp.525-530, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2011-06-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
We report the importance of elevated serum lactate dehydrogenase (LDH) and neutrophil a (NT) in two renal transplant recipients who developed renal impairment in the early post-operative period.
One of our recipients developed oliguria and increased serum cretonne with unexplained elevation of LDH and NT.
The biopsy was C4d positive with platelet and fibrin thrombi in the glomerular capillaries and arterioles and interpreted as acute vacuities or thrombotic form of antibody-mediated rejection (VAMR) with positive donor-specific antibodies (DSA).
Despite intensive treatment, this graft was lost.
When another patient developed a similar picture, prompt immunoadsorption was started without waiting for a confirmatory biopsy or DSA, and both were later reported as positive.
Improvement in renal function was associated with decreasing levels of LDH and NT.
Neither of these was elevated in cases of acute cellular rejection (ACR) or antibody mediated rejection (AMR) with isolated tubular injury (TAMR).
It may therefore be reasonable to assume that LDH and NT are potential diagnostic and prognostic markers of VAMR.
American Psychological Association (APA)
Khan, Taqi Toufeeq& Mirza, Anzar Baig& Zahid, Rafat& al-Husayni, Hassah& al-Sulayman, Muhammad H.& Mousa, Dujana…[et al.]. 2011. Antibody-mediated rejection : importance of lactate dehydrogenase and neutrophilia in early diagnosis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 22, no. 3, pp.525-530.
https://search.emarefa.net/detail/BIM-268399
Modern Language Association (MLA)
Khan, Taqi Toufeeq…[et al.]. Antibody-mediated rejection : importance of lactate dehydrogenase and neutrophilia in early diagnosis. Saudi Journal of Kidney Diseases and Transplantation Vol. 22, no. 3 (Jun. 2011), pp.525-530.
https://search.emarefa.net/detail/BIM-268399
American Medical Association (AMA)
Khan, Taqi Toufeeq& Mirza, Anzar Baig& Zahid, Rafat& al-Husayni, Hassah& al-Sulayman, Muhammad H.& Mousa, Dujana…[et al.]. Antibody-mediated rejection : importance of lactate dehydrogenase and neutrophilia in early diagnosis. Saudi Journal of Kidney Diseases and Transplantation. 2011. Vol. 22, no. 3, pp.525-530.
https://search.emarefa.net/detail/BIM-268399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 530
Record ID
BIM-268399