Study of cytotoxic effects alcoholic nerium oleander l. extract on female albino mice

Abstract EN

.This study involved the evaluation of Alcoholic extract of Noricum Oleander L.

plant that have a promising anticancer cell.

This extract was compared to the well-known anticancer drug Cis–Platinum by utilizing an in vivo system in female Albino mice.

The first direction was cytogenetically using the mitotic Index of bone marrow cells as a parameter for the cytotoxic effect of this extract.

The second direction was enzymatically using a widely distributed enzyme GOT in the different organs of mice : Liver, kidney, spleen and lung.

Animals were treated with three doses of Cis-platin, 50, 200 and 350 Mg / mouse for three days.

The same doses were used for the other extract.

This study showed that the extract have a promising anticancer cell as could be seen from these effect on mitotic Index (MI) of mice bone marrow, (MI) decreased in animals treated with different doses of extract, mitotic index was reduced to 78 % on day three in animals treated with 350 μg / mouse.

These effects were similar to the effect of Cis-platin at the same doses.

Comparing the effect of this extract on GOT enzyme showed that Cis-platin was more effective on activating the spleen GOT enzyme of about 95% than the extract while the extract is more effective in Lung, The extract activated GOT enzyme activity in the all organs.