Reaction of thiols with formaldehyde in presnce of succinimid and reduction of phenyl tetrazole derivative with hydrogen and borohydraide

Abstract EN

One of most the important compounds which have active hydrogen (substrate) is the toils which used in a wide field in preparation of Mannish bases.

A large number of Mannish bases have been prepared as a biologically active compound (pharmaceutical, pesticides, bactericidal, fungicidal and tuberculostatic) and in order to correlate their structure and reactivity with their pharmacological activity such as.

It has been reported that the reaction is easily preceded by using primary and secondary amine beside formaldehyde.

But when we tried the reaction of toils as substrate and formaldehyde and succinimide instead of amine, the reaction did not proceed to give Mannish base but product were methylbenzene– bis–sulfide.

Mannish base can go farther reaction such as (addition, substitution, cleavage, polymerization, and hydrogenation) to produce numerous numbers of compounds so we tried to hydrogenation tetrazole derivative which gave different product which deepened on type of hydrogen on reagent.

Reduction of 2–ethyl benzoyl–phenyl tetrazole which performed with hydrogen gas in methanol solution in presence palladium on carbon as catalyst, the tow products were separated by column chromatography.

Reduction of 2–methyl–2 (2–cycloheptane)–5- phenyl tetrazole.

The methanol solution the ketone was refluxed with equimolar amount of potassium borohydride and the product is isolated and purified to give.

And identified by C.H.N analysis and NMR spectra