Effect of combined paracetamol and glycyrrhizin glabra or cinnamomum zeylanicumuse in rats

Abstract EN

n this study we decided to throw light on some toxicological aspects of combined usage of Paracetamol with or without Glycyrrhiza glabra or Cinnamomum zeylanicum in rats.

Seven groups each of six male Wistar rats (12 weeks-old) were used in this study.

Paracetamol was provided to the first 2 groups at dose level of 500mg/L (in drinking water) or 500mg/kg (in feed), respectively.

The third group received a diet containing 6% w/w G.

glabra, a fourth group received a diet containing 6% w/w C.

zeylanicum, and additional 2 groups received mixture of paracetamol at 500mg/kg and G.

glabra or C zeylanicum for 2 and 4 weeks.

The last group remained without treatment as control group.

Hepato-nephropathy was observed in the rats fed the diet containing paracetamol at 500mg/L and 500 mg/kg.

Anaemia was recorded in rats supplemented with G glabra.

Decrease in haemoglobin level, increase in serum aspartate amino transferase (AST) activity and urea concentration were appearing in rats fed C.

zeylanicum.

Anaemia, increase activity of (AST) and increase in albumin level were observed in rats fed paracetamol and G.

glabra.

Increase in urea concentration in rats fed paracetamol and C.

zeylanicum.

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