HCV genotype and "silent' HBV confections : two main isk factors for a more severe liver disease
Joint Authors
Rajih, Ibrahim
Abd al-Aziz, Majidah
Abd al-Rahman, Suhayr
al-Sharnubi, Amal
al-Sharawi, Ahmad
Source
Tanta Medical Sciences Journal
Issue
Vol. 2, Issue 1 (31 Mar. 2007), pp.15-26, 12 p.
Publisher
Tanta Medical Sciences Society
Publication Date
2007-03-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Topics
Abstract EN
Aim : to evaluate whether HCV ecotype and "silent" HBV infection may be related to a more severe clinical presentation of liver disease.
Patients & Methods : 40 anti-HCV / HCV-RNA positive, HBsAg / anti-HBs negative patients with chronic hepatitis (27 males and 13 females, median ae 43+6.98) years, were studied on presentation at National Liver Institute, Menifee University.
Presence of serum anti-HBc, in absence of HBsAg and anti-HBs, was considered a marker of "silent" HBV infection.
Two main diagnosis groups were established: the mild liver disease group (Gl n = 20), and the severe liver disease group (G2 n = 20).
Results : the prevalence of silent HBV infection in HCV patients was 50 % where out of the 40 anti-HCV / HCV-RNA positive, HBsAg and anti-HBs negative patients with a definite diagnosis, 20 patients (50 %) were anti-HBc positive.
Of the 20 anti-HBc positive patients, HBeAg /anti-HBc system was investigated, where 14 patients (70 %) were anti-HBe positive and 6 patients (30 %) were anti-HBe negative.
None of these 20 patients was HBeA positive.
Twelve (60 %) out of the 20 HBcAb + ve cases were found to be positive for serum HBV-DNA by PCR.
In the present study, it was found that the prevalence of a severe liver disease was higher in anti-HBc positive cirrhotic HCV patients lackin both HBsAg and anti-HBs (silent HBV infection) than in cirrhotic HCV patients with no markers of HBV infection (80 % vs.
20 %, P < 0.001), indicating that a "silent HBV infection" may unfavorably influence the course of the disease.
This was observed both in HBV-DNA positive and in HBV-DNA negative patients and regardless HCV genotype.
Conclusion : Silent HBV infection seems to be a major risk factor for an unfavorable course of the disease.
The observation that anti-HBc positive / HBV-DNA negative patients show a similar prevalence of severe liver disease to anti-HBc / HBV-DNA positive patients and a significantly higher prevalence than anti-HBc negative cases supports further the view that isolated serum anti-HBc is a marker of clinical significance.
American Psychological Association (APA)
al-Sharawi, Ahmad& Abd al-Aziz, Majidah& Abd al-Rahman, Suhayr& Rajih, Ibrahim& al-Sharnubi, Amal. 2007. HCV genotype and "silent' HBV confections : two main isk factors for a more severe liver disease. Tanta Medical Sciences Journal،Vol. 2, no. 1, pp.15-26.
https://search.emarefa.net/detail/BIM-269518
Modern Language Association (MLA)
al-Sharawi, Ahmad…[et al.]. HCV genotype and "silent' HBV confections : two main isk factors for a more severe liver disease. Tanta Medical Sciences Journal Vol. 2, no. 1 (Mar. 2007), pp.15-26.
https://search.emarefa.net/detail/BIM-269518
American Medical Association (AMA)
al-Sharawi, Ahmad& Abd al-Aziz, Majidah& Abd al-Rahman, Suhayr& Rajih, Ibrahim& al-Sharnubi, Amal. HCV genotype and "silent' HBV confections : two main isk factors for a more severe liver disease. Tanta Medical Sciences Journal. 2007. Vol. 2, no. 1, pp.15-26.
https://search.emarefa.net/detail/BIM-269518
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 25-26
Record ID
BIM-269518