Maternal and fetal evaluation n patients with preeclampsia managed by transdermal nitroglycerine patch

Abstract EN

Background / Aim: the more advanced technology of Doppler velocimetry has been shown that statistically significant associations exist between abnormal Doppler waveforms and pregnancy complications as well adverse parental outcomes.

The aim of this study was to evaluate the mater ml and feel outcome in patients with mild preeclampsia treated by nitroglycerine transdermal patch.

Patients & Methods : 50 pregnant women were included in this study; they were divided into two groups.

Group included 10 healthy pregnant females Control group).

Group Included 40 pregnant females with mild preeclampsia.

Group II was subdivided into two subgroups: subgroup A included 10 pregnant females with mild preeclampsia who had undergone expectant management and subgroup B eluded 30 pregnant females with mild preeclampsia managed by nitroglycerine transdermal patches (nitric oxide donor).

The gestational age was 30 weeks or more for all tie studied women The studied women were evaluated through a detailed history, physical examination, routine investigations and ultrasound and opener study.

The composite ultrasonic study included feel deposition, fetal structure, fetal size, feel well-being placental site and grading and the amniotic fluid index.

Opener study included the measurement of the uterine artery S / Duration R], the umbilical arteryS / Dand PI, andfetal middle cerebral artery PI.

Mtroderm pitches were given once daily to be changed every 24 hours for the preeclampsia subgroup IB.

Ultrasound and opener studies were repeated every2 weeks for preeclampsia patients' undergone expectant management and every week for the preeclampsia patients managed with Mtroderm patches.

The healthy pregnant females were subjected to routine follow up every2 weeks.

Results: it was found that ritroderm patches succeeded in lowering the maternal blood pressure (Both systolic and diastolic), improved maternal disease control and increased amniotic fluid index.

There was improvement of the uteroplacental and fetoplacental blood flow with subsequent reductions in the uterine artery S / Dratio & Rl, the umbilical artery S / D ratio & H.

The fetal cerebral circulation rot affected with subsequent no change of MCA-PI.

The mean gestational age at the time of onset of lab our had been significantly reduced in preeclampsia patients with subsequent preterm deli very.

Apgar scores and neonatal weight were significantly lower in preeclampsia patients in comparison to the healthy pregnant controls.

This may be attributed to preterm delivery.

Conclusion : from this study, we can conclude that nitroglycerine transdermal path is a promising lire of treatment of preedampsia as it controls the maternal disease, allow safe continuation of pregnancy and doesn't ad versed affect the fetus but may even improve the fetal condition in utero.