Immunoglobulins assessment (IgE, G, A, M)‎ in some Iraqi patients with acute and chronic urticaria

Abstract EN

60 patients diagnosed as having urticarial were included in the study ; 30 patients were effected with acute urticarial and 30 patients were affected with chronic urticarial.

In addition, 30 healthy adult volunteers were selected as control group.

The patients and control groups sera were examined with enzyme linked immunosorbent assay (ELISA) to detect total level IgE and radial immunodiffusion (RID) to detect levels of IgG, IgA and IgM.

The total level of IgE in acute urticarial (1.45 ± 0.13) IU / mL and chronic urticarial (2.12 ± 0.10) IU / mL patients were significantly higher than the control groups (0.85 ± 0.10) IU / mL (p < 0.05).

The level of IgG in acute urticarial (12.5 ± 0.42) g / L and chronic (13.16 ± 0.40) g / L patients, IgA in acute (2.5±0.2)g/L and chronic (2.39±0.19)g/L patients, and IgM in acute (1.75 ± 0.11) g / L and chronic (1.47 ± 0.07) g / L , patients were also significantly higher the control groups (9.79 ± 0.81) g / L, (1.63 ± 0.14) g / L and (1.19 ± 0.07) g / L respectively.

The level of IgE was higher in the chronic urticarial patients than the acute urticarial stressing the importance of type-I hypersensitivity reaction in chronic urticarial.

While the level of IgM was significantly higher in the acute urticarial patients than the chronic urticaria which may suggest that some cases of acute urticarial were caused by acute infections.