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The value of immunohistochemical markers in pleomorphic adenoma and adenoid cystic carcinoma of the salivary gland
Joint Authors
Ashraf, M. J.
Shaghasemi, S.
Azarpira, Negar
Bagheri, Nazila
Khademi, Bijan
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 11, Issue 4 (31 Oct. 2009), pp.414-418, 5 p.
Publisher
Publication Date
2009-10-31
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : In recent years, immunohistochemical markers have provided considerable contribution to salivary gland tumor diagnosis and classification.
The aim of this study was to evaluate diagnostic value of various cytokeratin markers and smooth muscle actin (SMA) in differential diagnosis of pleomorphic adenoma (PA) and adenoid cystic carcinoma (ACC).
Methods : In this retrospective study, 35 cases of salivary gland tumors composed of 19 PA and 16 ACC were selected and immunohistochemical staining with six cytokeratin markers (CK7, CK8, CK13, CK14, CK17 and CK18) and SMA were performed.
The positivity of these markers in both typical and atypical areas of each tumor was compared.
Positivity was defined if 10% or more of the cells were immunostained.
Results : In the PA group, there was no difference between luminal and stromal expression of CK7, CK 8, CK 13, CK 14, CK 17, and CK 18 in both typical and atypical areas except SMA that was not expressed in the atypical area.
No statistically significant differences were found between the expression of CK7, CK 8, CK 14 and CK 18 in both typical and atypical areas of ACC group, with no expression of SMA in atypical area.
Conclusion : It seems that the immunoprofile of the atypical area of both PA and ACC are similar to each other and IHC does not help to differentiate them.
American Psychological Association (APA)
Ashraf, M. J.& Azarpira, Negar& Khademi, Bijan& Shaghasemi, S.& Bagheri, Nazila. 2009. The value of immunohistochemical markers in pleomorphic adenoma and adenoid cystic carcinoma of the salivary gland. Iranian Red Crescent Medical Journal،Vol. 11, no. 4, pp.414-418.
https://search.emarefa.net/detail/BIM-27222
Modern Language Association (MLA)
Ashraf, M. J.…[et al.]. The value of immunohistochemical markers in pleomorphic adenoma and adenoid cystic carcinoma of the salivary gland. Iranian Red Crescent Medical Journal Vol. 11, no. 4 (Oct. 2009), pp.414-418.
https://search.emarefa.net/detail/BIM-27222
American Medical Association (AMA)
Ashraf, M. J.& Azarpira, Negar& Khademi, Bijan& Shaghasemi, S.& Bagheri, Nazila. The value of immunohistochemical markers in pleomorphic adenoma and adenoid cystic carcinoma of the salivary gland. Iranian Red Crescent Medical Journal. 2009. Vol. 11, no. 4, pp.414-418.
https://search.emarefa.net/detail/BIM-27222
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 417-418
Record ID
BIM-27222