Tissue plasminogen and plasminogen activator inhibitor-1 serum level in osteoarthritis and rheumatoid arthritis patients

Abstract EN

Methodology : the activity of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) in the plasma of 40 rheumatoid arthritis (RA) patients (G1) and 10 osteoarthritis (OA) patients (G2) was measured.

Group I mean age was 40.95 ± 3.57 and the duration of disease was 91.65 ± 37.93 weeks.

Group II mean age was 50.87 ± 5.39 and the duration of disease was 77.43 ± 12.75 weeks.

Ten apparently healthy subjects were examined as a control group (G3).

Their mean age was 25.44 ± 10.45.

Results : the relationship between plasma t-PA and PAI-1 and their correlation with disease activity were studied in patients with rheumatoid arthritis (RA = G1) & (OA = G2), and control group a comparative study group showed that, RA G1 increased t-PA and PAI-1 activity, in comparison with OA patients and control group.

In addition, there was an imbalance between plasminogen activator inhibitor-type 1 (PAI-1) and t-PA in RA than OA patient or control.

Conclusions : these results show an alteration of the PAI-1 / t-PA system in RA, which increases with disease activity.

This alteration may play a role in joint destruction in RA.