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Formulation design and evaluation of self micro emulsifying drug delivery system (SMEDDS) of valproic acid
Other Title(s)
توليف و تقييم نظام لايصال دواء valproic acid عن طريق الاستحلاب الذاتي المتناهي الصغر
Joint Authors
Patro, Nagaraju
Yadav, Adhikrao V.
Source
Jordan Journal of Pharmaceutical Sciences
Issue
Vol. 3, Issue 2 (31 Jul. 2010), pp.117-125, 9 p.
Publisher
University of Jordan Deanship of Academic Research (DAR)
Publication Date
2010-07-31
Country of Publication
Jordan
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Topics
Abstract AR
يهدف هذا البحث لتطوير نظام إيصال valproic acid عن طريق الاستحلاب الذاتي المتناهي الصفر.
كما يهدف إلى تقييم فاعليته خارج الجسم كي تم تحديد ذائبية دواء valproic acid في سوائل مختلفة و تم استعمال رسومات مرحلة التواجد الثلاثي لتقييم وجود مساحة المستحلب و تم حساب سرعة انفلات الدواء عن طريق فحص الذائبية.
يتمتع هذا النظام بخاصية النقاء و التوريع لحجم الجزيئات المكونة له.
عملية التوليف و الفحص تم عملها بالاعتماد على نتائج الذائبية و الرسم الثلاثي المستحلب.
و قد كانت التوليفة المتالية تتكون 384 % bcasbroil و Cremaplor RH (42.4 %) و (14.4 %) و أظهرت التوليفة تحرزا كاملا خلال 15 دقيقة و نجحت في جميع اختبارات الشبات.
Abstract EN
The present investigation was aimed at developing a stable self micro emulsifying drug delivery system (SMEDDS) of valproic acid (VPA) and evaluating its in vitro potential.
The solubility of VPA was determined in various vehicles.
Pseudoternary phase diagrams were used to evaluate the micro emulsification existence area and the release rate of VPA was investigated using a dissolution method.
SMEDDS were characterized for clarity, precipitation and particle size distribution.
Formulation development and screening was done based on results of solubility from phase diagram.
The optimized formulation used for in vitro dissolution was composed of castor oil (38.4 %), Cremaphor RH 40 (42.4 %), PEG 400 (14.4 %).
The SMEDDS formulation showed complete release in 15 min.
as compared with the plain drug and conventional marketed formulation which showed a limited dissolution rate.
VPA loaded SMEDDS were subjected to various conditions of storage as per ICH guidelines for 3 months.
VPA SMEDDS successfully withstood the stability testing.
It has been found that dissolution profile of valproic acid from SMEDDS was much improved than valproic acid.
Keywords: SMEDDS; Valproic acid; Pseudo-ternary Diagram; Poorly Water Soluble Drug, Formulation.
American Psychological Association (APA)
Patro, Nagaraju& Yadav, Adhikrao V.. 2010. Formulation design and evaluation of self micro emulsifying drug delivery system (SMEDDS) of valproic acid. Jordan Journal of Pharmaceutical Sciences،Vol. 3, no. 2, pp.117-125.
https://search.emarefa.net/detail/BIM-272716
Modern Language Association (MLA)
Patro, Nagaraju& Yadav, Adhikrao V.. Formulation design and evaluation of self micro emulsifying drug delivery system (SMEDDS) of valproic acid. Jordan Journal of Pharmaceutical Sciences Vol. 3, no. 2 (Jul. 2010), pp.117-125.
https://search.emarefa.net/detail/BIM-272716
American Medical Association (AMA)
Patro, Nagaraju& Yadav, Adhikrao V.. Formulation design and evaluation of self micro emulsifying drug delivery system (SMEDDS) of valproic acid. Jordan Journal of Pharmaceutical Sciences. 2010. Vol. 3, no. 2, pp.117-125.
https://search.emarefa.net/detail/BIM-272716
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 123-124
Record ID
BIM-272716