تجريع تراكيز من حامض الفوليك و مستويات بعض أنزيمات مصل الدم في كباش الأغنام العواسية

Abstract EN

This experiment was conducted to investigate the effect of various levels of folic acid on some serum enzymes activity of Awassi rams.

Twelve rams of 1.5 years old and 50-60 kg body weight were randomly divided into 3 equal groups.

First group was left without treatment and regarded as control group (C), while the second group T1 and third group T2 were treated with 100 and 200 mg of folic acid/ head, respectively as two dose per week for 8 weeks treatment period.

Blood samples were collected before and after 4 and 8 weeks from the beginning of experiment.

Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) as well as alkaline phosphatase (ALP) activities were measured.

AST activity was significantly increased (P<0.05) after 8 weeks of treatment as compared with its activity before and after 4 weeks of treatment.

Folic acid did not affect ALT and ALP activity, however, their activity decreased significantly (P<0.05) after 4 and 8 weeks for ALT enzyme and 8 weeks for ALP enzyme as compared with their initial activity.

It can be concluded that Awassi sheep rams treated with folic acid leads to resultant a positive altering in the levels of studied enzymes as a result of improved metabolic processes and preserve the integrity of liver cells and prevent cases of necrosis and apoptosis in it.