Antioxidants activity of coriander sativum l. And hepatoprotective role against ccl4-induced oxidative stress in rats

Abstract EN

The present study was examined to investigate the possible hepatoprotective of the natural antioxidants of Coriander stadium L.

seed powder 10 % and Coriander essential oil 290 mg / kg diet against CcU-induced oxidative stress in Sprague-Daley albino rats.

The rats were divided into two main groups.

The first (6 rats) fed on the basal diet as a negative control group.

The second group (24 rats) treated with CcU in paraffin oil (50 % v / v 2 ml / kg) twice a week intraperitoneal injection and divided into four groups (6 rats each) according to the following scheme for 30 days : (1) positive control (received basal diet), group (2) received basal diet with 25mg / kg silymarin, (3) received basal diet with coriander seed powder 10 %), (4) received basal diet with coriander essential oil (290 mg / kg)diet.

Intraperitoneal injection of Celt resulted in significantly increase in the serum levels of aspartate transaminase (AST) and alanine transaminase (ALT) with the reduction of antioxidant enzymes.

Serum total protein and albumin levels were elevated by coriander essential oil and coriander seed powder against CcU-treated rats.

Kidney and liver functions were improved by a significant increase in antioxidant enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px).

Histopathologically examination showed that liver injury, large local area of hepatocytes necrosis which completely replaced by massive infiltration with leucocyte of CcU-treated rats.

Coriander essential oil activity has significant reduction of the toxic effect of CcU when compared to control positive group might be correlated with its antioxidant constituents and free radicals scavenger effects.