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The effect of intravenous tranexamic acid on blood loss in lumbar hernial disc resection under inhalation and total intravenous anesthesia
Joint Authors
Taghaddomi, R. Jalaeian
Mashhadinezhad, H.
Attar, A. R. Sharifian
Peivandi, A.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 11, Issue 3 (31 Jul. 2009), pp.265-270, 6 p.
Publisher
Publication Date
2009-07-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : tranexamic acid is a synthetic antifibrinolytic drug that reduces bleeding and transfusion requirements in cardiac surgery and total knee arthroplasty.
In this study, we evaluated the efficacy of the prophylactic tranexamic acid on intraoperative bleeding in patients undergoing lumbar hernial dices resection.
Methods : eighty patients in ASA class I and II were randomized into 4 groups.
In group 1, anesthesia was achieved by total intravenous anesthesia and also the administration of tranexamic acid.
The other groups were group 2, anesthetized by total intravenous anesthesia without tranexamic acid; group 3, anesthetized by halothane and the administration of tranexamic acid and group 4, anesthetized by halothane without tranexamic acid.
Blood loss and surgeon's satisfaction were registered.
Results : The amount of blood loss in group 1 was 267.1 ± 177.3 ml ; in group 2 : 656 ± 411.6 ml ; in group 3 : 357 ± 307.2 ml and in group 4 : 550 ± 406.7 ml.
The least bleeding was recorded in group 1 which had a significant difference with groups 2 and 4 for which tranexamic acid was not administered.
Blood loss in groups 2 and 4 was more or less similar with no significant difference.
The surgeon's highest satisfaction was with group 1.
No complications were recorded in the 4 groups.
Conclusion : we concluded that administration of prophylactic tranexamic acid in patients undergoing hernia disc resection has the potential to reduce intraoperative bleeding and improving visualization of the surgical field especially when administered with total intravenous anesthesia.
American Psychological Association (APA)
Taghaddomi, R. Jalaeian& Mashhadinezhad, H.& Attar, A. R. Sharifian& Peivandi, A.. 2009. The effect of intravenous tranexamic acid on blood loss in lumbar hernial disc resection under inhalation and total intravenous anesthesia. Iranian Red Crescent Medical Journal،Vol. 11, no. 3, pp.265-270.
https://search.emarefa.net/detail/BIM-27320
Modern Language Association (MLA)
Taghaddomi, R. Jalaeian…[et al.]. The effect of intravenous tranexamic acid on blood loss in lumbar hernial disc resection under inhalation and total intravenous anesthesia. Iranian Red Crescent Medical Journal Vol. 11, no. 3 (Jul. 2009), pp.265-270.
https://search.emarefa.net/detail/BIM-27320
American Medical Association (AMA)
Taghaddomi, R. Jalaeian& Mashhadinezhad, H.& Attar, A. R. Sharifian& Peivandi, A.. The effect of intravenous tranexamic acid on blood loss in lumbar hernial disc resection under inhalation and total intravenous anesthesia. Iranian Red Crescent Medical Journal. 2009. Vol. 11, no. 3, pp.265-270.
https://search.emarefa.net/detail/BIM-27320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 269-270
Record ID
BIM-27320