Soluble form of fasl (sFasL) in adult asthma
Joint Authors
Pourfathollah, A. A.
Pourpak, Z.
Heidarnazhad, H.
Daneshmandi, S.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 11, Issue 3 (31 Jul. 2009), pp.301-305, 5 p.
Publisher
Publication Date
2009-07-31
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : sFasL is the soluble form of FasL inducing apoptosis by binding to Fas.
Fas / sFasL could be the most important mechanisms in inflammatory conditions such as asthma by controlling inflammatory responses.
This study was undertaken to determine the level of sFasL in allergic and non-allergic asthmatic patients with different stages of asthma control.
Methods : twenty asthmatic patients were enrolled and divided into controlled and uncontrolled patient groups.
They were divided into 4 subgroups including controlled / allergic, controlled / non-allergic, uncontrolled / allergic and uncontrolled / non-allergic subgroups.
Five normal subjects were selected as a control group.
From all subjects, 3 ml of blood was obtained and sFasL and IgE serum levels were evaluated by a specific ELISA kit.
Results : sFasL in the controlled and uncontrolled patient groups did not have any significant difference ; but in the uncontrolled / allergic subgroup, it was significantly lower than that in the control group and also higher in the uncontrolled / non-allergic subgroup insignificantly.
Conclusion : In patients with acute inflammatory conditions, sFasL had an increasing effect to control inflammation observed in uncontrolled / non-allergic subgroup, but unexpectedly not in the uncontrolled / allergic subgroup.
Probably in allergic patients, there are factors or mechanisms that inhibit sFasL production or expression.
American Psychological Association (APA)
Daneshmandi, S.& Pourfathollah, A. A.& Pourpak, Z.& Heidarnazhad, H.. 2009. Soluble form of fasl (sFasL) in adult asthma. Iranian Red Crescent Medical Journal،Vol. 11, no. 3, pp.301-305.
https://search.emarefa.net/detail/BIM-27361
Modern Language Association (MLA)
Daneshmandi, S.…[et al.]. Soluble form of fasl (sFasL) in adult asthma. Iranian Red Crescent Medical Journal Vol. 11, no. 3 (Jul. 2009), pp.301-305.
https://search.emarefa.net/detail/BIM-27361
American Medical Association (AMA)
Daneshmandi, S.& Pourfathollah, A. A.& Pourpak, Z.& Heidarnazhad, H.. Soluble form of fasl (sFasL) in adult asthma. Iranian Red Crescent Medical Journal. 2009. Vol. 11, no. 3, pp.301-305.
https://search.emarefa.net/detail/BIM-27361
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 304-305
Record ID
BIM-27361