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Outcome and prognostic factors of uterine sarcoma in 59 patients: single institutional results
Joint Authors
Nassar, Umayyah Abd al-Hamid
Abd al-Muti, Sharif Baha al-Din
Khalil, al-Sayyid Ashraf
al-Najjar, Mirfat
al-Tahir, Maha Muhammad
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 22, Issue 2 (30 Jun. 2010), pp.113-122, 10 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2010-06-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Topics
Abstract EN
Purpose : Uterine corpus sarcomas are rare heterogeneous tumors characterized by rapid progression and poor response to treatment.
This series investigated treatment options, relapse pattern, survival and prognostic factors.
Patients and Methods: A total of 59 patients were treated in the National Cancer Institute, Cairo University, (2000-2007).
Leiomyosarcoma accounted for 42.2 % followed by carcinosarcoma (35.5 %) and endometrial stromal sarcoma (18.6 %).
40.7 % had FIGO stage I disease, 30.5 % were II, 16.9 % were III and 11.9 % were IV.
Surgery was the primary line of treatment for all cases with total abdominal hysterectomy and bilateral salpingoophorectomy in 88 % of cases and 12 % had less extensive surgery.
Twenty-four (40.7 %) patients had surgery alone, 24 (40.7 %) had surgery and radiotherapy, (11.9 %) had surgery and chemo-irradiation and 4 (6.7 %) had surgery and chemotherapy.
Results : After 27.4 months mean follow-up range : (2-69), relapses were detected in 32 patients (59.2%) including 19 (59 %) systemic metastases.
Stage, adjuvant irradiation, tumor size, myometrium invasion, vascular and cervix invasion were significant factors in univariate analysis ; nevertheless, multivariate prognostic factors were only stage (p = 0.04) and adjuvant irradiation (p = 0.01)) 5 year cumulative disease free survival for stage I was 41.2 %, 63.6 % for stage II, 10 % for stage III and 0 % in stage IV.
Neither extent of surgery, chemotherapy, histologic type or grade had significant effect on survival.
Adjuvant radiotherapy offered 62 % 2-year cumulative overall survival versus 22 % for surgery alone and surgery with chemotherapy.
Salvage surgery for isolated relapses was performed for 9 / 32 5recurrent patients (28 %) including lung metastatectomies and 4 local pelvic resections.
Mean survival after pulmonary resections was 7.4 months (6-14).
Conclusion : diagnosis of uterine sarcoma is in itself a poor prognostic factor.
Complete cytoreductive surgery and adjuvant radiotherapy is essential for local control, provided tumor is limited to the uterus.
Adjuvant irradiation showed survival benefit.
American Psychological Association (APA)
Nassar, Umayyah Abd al-Hamid& Abd al-Muti, Sharif Baha al-Din& Khalil, al-Sayyid Ashraf& al-Tahir, Maha Muhammad& al-Najjar, Mirfat. 2010. Outcome and prognostic factors of uterine sarcoma in 59 patients: single institutional results. Journal of the Egyptian National Cancer Institute،Vol. 22, no. 2, pp.113-122.
https://search.emarefa.net/detail/BIM-273801
Modern Language Association (MLA)
Nassar, Umayyah Abd al-Hamid…[et al.]. Outcome and prognostic factors of uterine sarcoma in 59 patients: single institutional results. Journal of the Egyptian National Cancer Institute Vol. 22, no. 2 (Jun. 2010), pp.113-122.
https://search.emarefa.net/detail/BIM-273801
American Medical Association (AMA)
Nassar, Umayyah Abd al-Hamid& Abd al-Muti, Sharif Baha al-Din& Khalil, al-Sayyid Ashraf& al-Tahir, Maha Muhammad& al-Najjar, Mirfat. Outcome and prognostic factors of uterine sarcoma in 59 patients: single institutional results. Journal of the Egyptian National Cancer Institute. 2010. Vol. 22, no. 2, pp.113-122.
https://search.emarefa.net/detail/BIM-273801
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 121-122
Record ID
BIM-273801