The role of 18-FDG positron emission tomography (FDG-PET) in detecting post-radiotherapy loco regional relapse residual disease in nasopharyngeal cancer
Joint Authors
al-Amr, Abd Allah
Salim, Muhammad
Bakhit, Sima
Larson, Sven
Janahi, Lubna
Powe, John
al-Sibai, Midhat M.
al-Rajihi, Nasir
Khafajah, Yasir
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 21, Issue 4 (31 Dec. 2009), pp.279-285, 7 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2009-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background : post-radiotherapy nasopharyngeal changes represent a diagnostic dilemma.
Early detection of persistent or recurrent disease may be translated to better cure rate if salvage therapy is implemented.
Neither clinical exam nor current radiological anatomical studies (CT / MRI) can differentiate between benign post therapy changes and recurrence.
PET scan is a functional study capable of identifying viable tumors as areas of increased radiotracer uptake.
Methods : Fifty-five patients underwent 18-FDG PET scans post radiation therapy for nasopharyngeal carcinoma at King Faisal Specialist Hospital and Research Centre.
We compared the 18-FDG PET scan with the clinical, radiological and pathological findings.
Results : clinical examination and CT of the head and neck showed post-treatment abnormality in the nasopharynx in 40 patients.
Among these, 28 patients had asymmetry in the CT scan.
Three out of the 28 patients had positive PET scan.
Out of the 12 patients with positive primary disease in the CT scan, 3 had negative PET scan which was also confirmed by biopsy in 2 patients.
Eleven patients had positive PET scan in the primary site ; this was pathologically confirmed to be recurrent disease in 5patients.
In 2 patients repeat PET scan was converted to negative.
The remaining 4 patients did not have biopsy due to the presence of concurrent distant disease.
None of the patients with negative PET scan in the neck exhibit recurrence or persistent neck disease to the day of reporting the study.
PET scan showed persistent higher sensitivity, specificity, positive and negative predictive values at both the primary site and the neck region than the CT did.
Conclusion : PET scan is a useful tool in differentiating between post radiotherapy fibrosis and recurrent nasopharyngeal cancer.
American Psychological Association (APA)
al-Amr, Abd Allah& Salim, Muhammad& Bakhit, Sima& Khafajah, Yasir& al-Rajihi, Nasir& Larson, Sven…[et al.]. 2009. The role of 18-FDG positron emission tomography (FDG-PET) in detecting post-radiotherapy loco regional relapse residual disease in nasopharyngeal cancer. Journal of the Egyptian National Cancer Institute،Vol. 21, no. 4, pp.279-285.
https://search.emarefa.net/detail/BIM-273898
Modern Language Association (MLA)
al-Amr, Abd Allah…[et al.]. The role of 18-FDG positron emission tomography (FDG-PET) in detecting post-radiotherapy loco regional relapse residual disease in nasopharyngeal cancer. Journal of the Egyptian National Cancer Institute Vol. 21, no. 4 (Dec. 2009), pp.279-285.
https://search.emarefa.net/detail/BIM-273898
American Medical Association (AMA)
al-Amr, Abd Allah& Salim, Muhammad& Bakhit, Sima& Khafajah, Yasir& al-Rajihi, Nasir& Larson, Sven…[et al.]. The role of 18-FDG positron emission tomography (FDG-PET) in detecting post-radiotherapy loco regional relapse residual disease in nasopharyngeal cancer. Journal of the Egyptian National Cancer Institute. 2009. Vol. 21, no. 4, pp.279-285.
https://search.emarefa.net/detail/BIM-273898
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 284-285
Record ID
BIM-273898