Experience with mycophenolate mofetil among Jordanian patients with myasthenia gravis

Abstract EN

Objectives : to investigate the short- term efficacy and safety of Mycophenolate Mufti treatment among Jordanian patients with refractory myasthenia gravis.

Methods : this study was conducted in King Hussein Medical Centre, Prince Rashed Hospital and Prince Hashem Hospital between January 2007 and January 2009.

The study included 18 patients with poorly controlled generalized moderate to severe myasthenia gravis despite treatment with Prednisolone alone or with Azathioprine.

All patients received my cophenolate Mofetil 1.5-2g daily for 9 months.

The primary efficacy measure was a reduction of three points in the manual muscle test score and / or a reduction of 50 % in corticosteroid dose.

Results : all patients completed the study.

Twelve patients improved, beginning after 3-5 months.

The maximum benefit was after 7 months of treatment.

No serious adverse effects were observed.

Conclusions : My cophenolate mofetil is a promising alternative to other currently available immunosuppressive drugs for the treatment of refractory myasthenia gravis.