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Cancer of oral cavity abutting the mandible; predictors of loco-regional failure
Joint Authors
Husayn, Hisham A.
Mebeed, Ali H.
Sami, Ihab
Farahat, Iman G.
Sabir, Tariq K. H.
al-Sibai, Hisham I.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 21, Issue 3 (30 Sep. 2009), pp.219-227, 9 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2009-09-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Topics
Abstract EN
Aim of Work: The purpose of this study is to analyze the causes of Loco-regional failure in 51 patients with tumors of the oral cavity abutting the mandible.
Patients and Methods : this cross-sectional study (27 patients were operated upon in the retrospective section and 24 patients in the prospective section of the study) was done in the department of Surgical Oncology, National Cancer Institute, Cairo University, from January 2003 to January 2008.
Fifty-One patients, with oral cavity cancerous lesions abutting the mandible, were operated upon b segmental mandibulectomy en-bloc with primary tumor resection in addition to modified radical or selective neck dissection according to the status of the cervical lymph nodes Results : during a median follow-up of 2 years, 29 patients (56.8 %) had local recurrences, the incidence of nodal recurrence after neck dissection was detected in 4 patients (7.8 %).
On multivariate analysis, tumor depth, tumor grade, oral mucosa, soft tissue and bone surgical margins in addition to metastatic lymphadenopathy were independent prognostic factors of loco-regional failure and disease-free survival.
Conclusion : oral cavity cancers abutting the mandible should be treated with great caution by a multidisciplinary oncology team (resection and reconstruction surgeons) as it has a very aggressive biologic behavior.
Negative intraoperative pathological margins should be attempted since this is the critical point for patients with cancers abutting the mandible? Further research on the biologic margin and genetic study is required.
American Psychological Association (APA)
Sabir, Tariq K. H.& Husayn, Hisham A.& Mebeed, Ali H.& al-Sibai, Hisham I.& Sami, Ihab& Farahat, Iman G.. 2009. Cancer of oral cavity abutting the mandible; predictors of loco-regional failure. Journal of the Egyptian National Cancer Institute،Vol. 21, no. 3, pp.219-227.
https://search.emarefa.net/detail/BIM-273947
Modern Language Association (MLA)
Sabir, Tariq K. H.…[et al.]. Cancer of oral cavity abutting the mandible; predictors of loco-regional failure. Journal of the Egyptian National Cancer Institute Vol. 21, no. 3 (Sep. 2009), pp.219-227.
https://search.emarefa.net/detail/BIM-273947
American Medical Association (AMA)
Sabir, Tariq K. H.& Husayn, Hisham A.& Mebeed, Ali H.& al-Sibai, Hisham I.& Sami, Ihab& Farahat, Iman G.. Cancer of oral cavity abutting the mandible; predictors of loco-regional failure. Journal of the Egyptian National Cancer Institute. 2009. Vol. 21, no. 3, pp.219-227.
https://search.emarefa.net/detail/BIM-273947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 226-227
Record ID
BIM-273947