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Immunohistochemical study of c-KIT (CD117) expression in renal cell carcinoma
Joint Authors
Ahmad, Iman Abd al-Zahir
Yusuf, Muhammad al-Sayyid
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 21, Issue 2 (30 Jun. 2009), pp.121-132, 12 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2009-06-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Topics
Abstract EN
Objective : certain subtypes of Renal cell carcinomas (RCCs) are diagnostically challenging owing to their overlapping histopathologically features.
Recently, c-KIT (CD117) has come into focus as a potential diagnostic marker of some renal tumors.
c-KIT also provides a potentially suitable for targeted tumor therapy.
The present study was designed to investigate the expression of c-KIT in RCCs in order to evaluate its diagnostic usefulness as a phenotypic marker and to establish the basis for a new possible therapeutic modality.
Material and Methods : the present work was conducted on 49 patients with RCC: Clear cell RCC (CRCC) : 30 cases (61.22%) ; homophobe RCC (ChRCC) : 9 cases (18.37 %) papillary RCC (PRCC), type I: 5 cases (10.20 %) ; and carcinoma of the collecting ducts of Bellini (CdRCC) : 5 cases (10.20 %).
The expression of c-KIT was assessed using immunohistochemistry.
The diagnostic performance of c-KIT expression was evaluated using ROC curve analysis.
Results : overall, 11 (22.5 %) cases of RCC showed c-KIT expression: 2 (6.7 %) CRCC, 7 (77.8 %) ChRCC, and 2 (40.0 %) CdRCC.
Among the study group, ChRCC had the highest frequency (p = .001) and staining score (p = .001) for c-KIT.
In addition, only ChRCC showed membranous pattern of c-KIT staining, while other tumors showed cytoplasmic staining (p =.013).
c-KIT showed a sensitivity of 77.78 % and a specificity of 95 % for the diagnosis of ChRCC.
The relation between c-KIT expression and clinic pathological parameters was not significant.
High grade tumors had a statistically significant higher total score of c-KIT expression (p = .023).
Conclusions : c-KIT is frequently and significantly expressed in chromophobe RCC suggesting that it might play a role in its pathogenesis.
Immunohistochemical detection of c-KIT expression could be used to aid histological diagnosis of homophobe RCC with a high sensitivity and specificity.
The substantial c-Kit immunoreactivity in homophobe RCC may be of clinical importance especially in the field of targeted therapy.
American Psychological Association (APA)
Ahmad, Iman Abd al-Zahir& Yusuf, Muhammad al-Sayyid. 2009. Immunohistochemical study of c-KIT (CD117) expression in renal cell carcinoma. Journal of the Egyptian National Cancer Institute،Vol. 21, no. 2, pp.121-132.
https://search.emarefa.net/detail/BIM-273982
Modern Language Association (MLA)
Ahmad, Iman Abd al-Zahir& Yusuf, Muhammad al-Sayyid. Immunohistochemical study of c-KIT (CD117) expression in renal cell carcinoma. Journal of the Egyptian National Cancer Institute Vol. 21, no. 2 (Jun. 2009), pp.121-132.
https://search.emarefa.net/detail/BIM-273982
American Medical Association (AMA)
Ahmad, Iman Abd al-Zahir& Yusuf, Muhammad al-Sayyid. Immunohistochemical study of c-KIT (CD117) expression in renal cell carcinoma. Journal of the Egyptian National Cancer Institute. 2009. Vol. 21, no. 2, pp.121-132.
https://search.emarefa.net/detail/BIM-273982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 130-132
Record ID
BIM-273982