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Clinical experience with radiotherapy alone and radiochemotherapy with platin based regimens in organ-sparing treatment of invasive bladder cancer
Joint Authors
Jamal al-Din, Hanan Sh.
al-Shadhili, Halah F.
Abu Zaynah, Isam A.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 21, Issue 1 (31 Mar. 2009), pp.59-70, 12 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2009-03-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Topics
Abstract EN
Purpose : to evaluate experience with combined modality treatment and selective bladder preservation and to identify factors that may predict treatment response, risk of relapse, and survival Patients and Methods: Between January 1998 and January 2007, 186 patients with muscle invasive transitional cell carcinoma (TCC) of the urinary bladder were treated with radiotherapy (RT ; n = 72), or radio chemotherapy (RCT ; n = 114) with plating based regimens after transurethral resection (TUR) of the tumor.
About 3 to 4 weeks after RT / RCT, response was evaluated by restaging-TUR.
In case of complete response (CR), patients were observed at regular intervals.
In case of persistent or recurrent invasive tumor, salvage-cystectomy was recommended.
Median follow-up was 58.8 months (range, 3.1 to 100.4 Months).
Results : complete response was achieved in 72.6 % of patients.
Local control after CR without any relapse was maintained in 70.9 % of patients at 5 years.
Distant metastases were diagnosed in 50 patients with an actuarial rate of 28.23 % at 5 years.
Five-year overall survival (OAS) was 64.82% for the whole group of patients, and it was 67.14 % for cases who preserved their bladder.
Early tumor stage, age < 60 years, low tumor grade, absence of pelvic lymph nodes, and a complete TUR were the most important significant factors predicting CR and survival.
RCT was more significantly effective than RT alone in development of CR.
Salvage cystectomy was associated with a 4.55 % disease-free survival rate and 30.78 % overall survival rate at 5 years.
Conclusion : Transurethral resection with radio chemotherapy are reasonable option for patients seeking an alternative to radical cystectomy.
Ideal candidates are those with early-stage, age < 60 years, low tumor grade, and absence of pelvic lymph nodes ; in whom a complete TUR is accomplished.
American Psychological Association (APA)
Jamal al-Din, Hanan Sh.& al-Shadhili, Halah F.& Abu Zaynah, Isam A.. 2009. Clinical experience with radiotherapy alone and radiochemotherapy with platin based regimens in organ-sparing treatment of invasive bladder cancer. Journal of the Egyptian National Cancer Institute،Vol. 21, no. 1, pp.59-70.
https://search.emarefa.net/detail/BIM-274027
Modern Language Association (MLA)
al-Shadhili, Halah F.…[et al.]. Clinical experience with radiotherapy alone and radiochemotherapy with platin based regimens in organ-sparing treatment of invasive bladder cancer. Journal of the Egyptian National Cancer Institute Vol. 21, no. 1 (Mar. 2009), pp.59-70.
https://search.emarefa.net/detail/BIM-274027
American Medical Association (AMA)
Jamal al-Din, Hanan Sh.& al-Shadhili, Halah F.& Abu Zaynah, Isam A.. Clinical experience with radiotherapy alone and radiochemotherapy with platin based regimens in organ-sparing treatment of invasive bladder cancer. Journal of the Egyptian National Cancer Institute. 2009. Vol. 21, no. 1, pp.59-70.
https://search.emarefa.net/detail/BIM-274027
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 68-70
Record ID
BIM-274027