P53 expression in endometrial carcinoma : an immunohistochemical study

Abstract EN

Objective: The current study aims to evaluate the immunohistochemical expression of p53 protein in patients with endometrial carcinoma in correlation with other parameters including estrogen receptor, and with results of other studies.

Methods: Sixty cases of endometrial carcinoma in which the estrogen receptor status was previously tested by immunohistochemical staining, were included in this study.

The endometrial carcinoma was detected in 15 endometrial curetting and 45 hysterectomy specimens.

The blocks of these cases were collected from Al Jumhuri Teaching hospital, AL-Khansaa and Al-Butool Teaching hospitals and private laboratories in Mosul city, during the period from January 2007 to January 2009.

Tumors were classified according to the World Health Organization classification system and graded according to FIGO grading system.

The expression of p53 protein was evaluated immunohistochemically.

Results: P53 expression was detected in 21 cases of endometrial carcinoma (35%).

The patients ages ranged from 40 to 70 years (mean=56.5 years), p53 expression has a statistically no significant relationship with patients’ age.

Fifty five cases (91.7%) were endometrioid carcinoma (type 1) and 5 cases (8.3%) were non-endometrioid carcinoma (type 2).

A statistically significant association was found between p53 expression and types of endometrial carcinoma (EC).

P53 expression was directly correlated with the grade of endometriod carcinoma and the extent of myometrial invasion.

Positive expression of p53 was inversly significantly associated with positive estrogen receptor (ER) cases.

About 75% of ER positive cases of EC (60%) failed to show p53 expression positivity.

Conclusions: P53 expression was found in 35% of endometrial carcinoma in Mosul city.

A significant association was found between p53 expression and tumor type.

P53 expression is directly correlated with the age of the patients, grade of endometrioid carcinoma and the extent of myometrial invasion.

On the other hand, there was a significant inverse relationship between p53 expression and estrogen receptor status.