The impact of type 2 diabetes mellitus on bone mass and bone turnover in postmenopausal females

Abstract EN

Objectives : osteoporosis is a prevalent bone disease characterized by a decrease in bone mass and altered bone architecture leading to increased fracture risk.

The present study aimed at evaluation of the impact of type 2 diabetes mellitus (T2DM) on bone mass and the status of bone turnover in postmenopausal females.

Methodology : In this cross sectional study we evaluated bone turnover and bone mineral density (BMD) in 39 postmenopausal T2DM and 25 non-diabetic postmenopausal females.

We measured serum levels of calcium, phosphate, osteocalcin, bone specific alkaline phosphatase (BS-ALP) and urinary excretion of c-terminal telopeptide cross links / cretonne ratio while BMD was evaluated by dual energy x-ray absorptiometry (DEXA).

Results : we found significantly higher BMD values for lumbar spine in the patients’ group, (0.828 g / cm2 for the study group and 0.720 g / cm2 for controls).

Levels of, BS-ALP, osteocalcin and c-terminal telopeptide cross links/creatinine ratio were significantly lower in the diabetic subjects (68.667U / L, 3.856 ng / ml and 4.157 mg / mg creatinine respectively in the patient group versus 94.640 U / L, 7.472 ng / ml and 5.851 mg / mg creatinine in the control group).

Conclusion: Our results suggested protective effect of T2DM on bone mass of lumbar spine together with decreased bone turnover in postmenopausal females.