Hepatoprotective activity of “orthosiphon stamineus” on liver damage caused by paracetamol in rats
Other Title(s)
نشاط حماية الكبد لمادة(orthosiphon stamineus) على تلف الكبد الناجم عن الباراسيتامول في الفئران
Joint Authors
Maheswari, C.
Maryammal, R.
Venkatanarayanan, R.
Source
Jordan Journal of Biological Sciences
Issue
Vol. 1, Issue 3 (30 Sep. 2008), pp.105-108, 4 p.
Publisher
The Hashemite University Deanship of Academic Research and Graduate
Publication Date
2008-09-30
Country of Publication
Jordan
No. of Pages
4
Main Subjects
Topics
Abstract EN
The objective of this study was to investigate the hepatoprotective activity of Methanol extract of leaves of Orthosiphon stamineus against paracetamol induced hepatotoxicity.
The material was dried in shade, they were powdered and Extracted with methanol.
Preliminary phytochemical tests were done.
Methanol extract showed presence of phenolic compound and flavonoids.
The hepatoprotective activity of the methanol extract was assessed in paracetamol induced hepatotoxic Rats.
Alteration in the levels of biochemical markers of hepatic damage like SGOT, SGPT, ALP and lipid peroxides were tested in both Paracetamol treated and untreaed groups.
Paracetamol (2g / kg) has enhanced the SGOT, SGPT, ALP and the Lipid peroxides in liver.
Treatment of methanol extract of O.Stamineus leaves (200mg / kg) has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner.
Our findings suggested that O.Stamineus methanol leaf extract possessed hepatoprotective activity.
American Psychological Association (APA)
Maheswari, C.& Maryammal, R.& Venkatanarayanan, R.. 2008. Hepatoprotective activity of “orthosiphon stamineus” on liver damage caused by paracetamol in rats. Jordan Journal of Biological Sciences،Vol. 1, no. 3, pp.105-108.
https://search.emarefa.net/detail/BIM-274443
Modern Language Association (MLA)
Maheswari, C.…[et al.]. Hepatoprotective activity of “orthosiphon stamineus” on liver damage caused by paracetamol in rats. Jordan Journal of Biological Sciences Vol. 1, no. 3 (Sep. 2008), pp.105-108.
https://search.emarefa.net/detail/BIM-274443
American Medical Association (AMA)
Maheswari, C.& Maryammal, R.& Venkatanarayanan, R.. Hepatoprotective activity of “orthosiphon stamineus” on liver damage caused by paracetamol in rats. Jordan Journal of Biological Sciences. 2008. Vol. 1, no. 3, pp.105-108.
https://search.emarefa.net/detail/BIM-274443
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 107-108
Record ID
BIM-274443