Investigation of drug polymer interaction: evaluation and characterization of diclofenac-chitosan co-precipitate

Other Title(s)

دراسة و تقييم التداخل بين معقد الكيتوسان و دواء الديكلوفيناك كراسب مشترك

Joint Authors

Hamdan, Imad
Bani Jabir, Ahmad
al-Anani, Dima
al-Khalidi, Bashshar A.

Source

Jordan Journal of Pharmaceutical Sciences

Issue

Vol. 2, Issue 2 (31 Jul. 2009), pp.140-149, 10 p.

Publisher

University of Jordan Deanship of Academic Research (DAR)

Publication Date

2009-07-31

Country of Publication

Jordan

No. of Pages

10

Main Subjects

Pharmacology

Abstract AR

الهدف من الدراسة هو دراسة التفاعل بين دواء الديكلوفيناك و معقد الكيتوسان.

لهذا الهدف تم دمج محاليل من الدواء و المعقد في ظروف تضمن التأين للدواء و المعقد و نتيجة لذلك تم الحصول على راسب مشترك.

تم تحليل الراسب بعدة طرق كيميائية و فيزيائية.

وجد أن الراسب هو خليط فيزيائي بين الدواء و المعقد بدون أي حصول تداخل ايوني بينهما.

بما أن المركبين كانا متائينين بما يكفي في ظروف التفاعل تم تفسير عدم التداخل الأيوني كنتيجة لعدم ثبات المعقد الأيوني.

Abstract EN

Investigating the interaction between Diclofenac and Chitosan and its effect on the dissolution in water and in Phosphate buffer system was the objective of this study.

Complex formation was attempted between diclofenac and chitosan utilizing optimal condition for their simultaneous ionization in solution form.

A co-precipitate was obtained upon mixing the drug and polymer solutions and the coprecipitate was characterized for drug content, differential scanning calorimetry (DSC), X-ray diffraction and infrared spectroscopy (FTIR) analysis in comparison to diclofenac sodium, diclofenac free acid and their physical mixtures with chitosan.

The overall evidence of these comparisons indicated that a physical co-precipitation of chitosan and diclofenac acid was formed with no electrostatic complexation.

Having diclofenac acid as a reference for comparison was the key for this conclusion, and comparing the results of the precipitate to only those of diclofenac sodium would have led to false conclusions.

The no complexation between the drug and polymer could not be explained based on lack of ionization of either molecule and was explained based on the instability of the complex.

American Psychological Association (APA)

Bani Jabir, Ahmad& al-Anani, Dima& Hamdan, Imad& al-Khalidi, Bashshar A.. 2009. Investigation of drug polymer interaction: evaluation and characterization of diclofenac-chitosan co-precipitate. Jordan Journal of Pharmaceutical Sciences،Vol. 2, no. 2, pp.140-149.
https://search.emarefa.net/detail/BIM-274479

Modern Language Association (MLA)

Bani Jabir, Ahmad…[et al.]. Investigation of drug polymer interaction: evaluation and characterization of diclofenac-chitosan co-precipitate. Jordan Journal of Pharmaceutical Sciences Vol. 2, no. 2 (2009), pp.140-149.
https://search.emarefa.net/detail/BIM-274479

American Medical Association (AMA)

Bani Jabir, Ahmad& al-Anani, Dima& Hamdan, Imad& al-Khalidi, Bashshar A.. Investigation of drug polymer interaction: evaluation and characterization of diclofenac-chitosan co-precipitate. Jordan Journal of Pharmaceutical Sciences. 2009. Vol. 2, no. 2, pp.140-149.
https://search.emarefa.net/detail/BIM-274479

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 148

Record ID

BIM-274479