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Investigation of drug polymer interaction: evaluation and characterization of diclofenac-chitosan co-precipitate
Other Title(s)
دراسة و تقييم التداخل بين معقد الكيتوسان و دواء الديكلوفيناك كراسب مشترك
Joint Authors
Hamdan, Imad
Bani Jabir, Ahmad
al-Anani, Dima
al-Khalidi, Bashshar A.
Source
Jordan Journal of Pharmaceutical Sciences
Issue
Vol. 2, Issue 2 (31 Jul. 2009), pp.140-149, 10 p.
Publisher
University of Jordan Deanship of Academic Research (DAR)
Publication Date
2009-07-31
Country of Publication
Jordan
No. of Pages
10
Main Subjects
Abstract AR
الهدف من الدراسة هو دراسة التفاعل بين دواء الديكلوفيناك و معقد الكيتوسان.
لهذا الهدف تم دمج محاليل من الدواء و المعقد في ظروف تضمن التأين للدواء و المعقد و نتيجة لذلك تم الحصول على راسب مشترك.
تم تحليل الراسب بعدة طرق كيميائية و فيزيائية.
وجد أن الراسب هو خليط فيزيائي بين الدواء و المعقد بدون أي حصول تداخل ايوني بينهما.
بما أن المركبين كانا متائينين بما يكفي في ظروف التفاعل تم تفسير عدم التداخل الأيوني كنتيجة لعدم ثبات المعقد الأيوني.
Abstract EN
Investigating the interaction between Diclofenac and Chitosan and its effect on the dissolution in water and in Phosphate buffer system was the objective of this study.
Complex formation was attempted between diclofenac and chitosan utilizing optimal condition for their simultaneous ionization in solution form.
A co-precipitate was obtained upon mixing the drug and polymer solutions and the coprecipitate was characterized for drug content, differential scanning calorimetry (DSC), X-ray diffraction and infrared spectroscopy (FTIR) analysis in comparison to diclofenac sodium, diclofenac free acid and their physical mixtures with chitosan.
The overall evidence of these comparisons indicated that a physical co-precipitation of chitosan and diclofenac acid was formed with no electrostatic complexation.
Having diclofenac acid as a reference for comparison was the key for this conclusion, and comparing the results of the precipitate to only those of diclofenac sodium would have led to false conclusions.
The no complexation between the drug and polymer could not be explained based on lack of ionization of either molecule and was explained based on the instability of the complex.
American Psychological Association (APA)
Bani Jabir, Ahmad& al-Anani, Dima& Hamdan, Imad& al-Khalidi, Bashshar A.. 2009. Investigation of drug polymer interaction: evaluation and characterization of diclofenac-chitosan co-precipitate. Jordan Journal of Pharmaceutical Sciences،Vol. 2, no. 2, pp.140-149.
https://search.emarefa.net/detail/BIM-274479
Modern Language Association (MLA)
Bani Jabir, Ahmad…[et al.]. Investigation of drug polymer interaction: evaluation and characterization of diclofenac-chitosan co-precipitate. Jordan Journal of Pharmaceutical Sciences Vol. 2, no. 2 (2009), pp.140-149.
https://search.emarefa.net/detail/BIM-274479
American Medical Association (AMA)
Bani Jabir, Ahmad& al-Anani, Dima& Hamdan, Imad& al-Khalidi, Bashshar A.. Investigation of drug polymer interaction: evaluation and characterization of diclofenac-chitosan co-precipitate. Jordan Journal of Pharmaceutical Sciences. 2009. Vol. 2, no. 2, pp.140-149.
https://search.emarefa.net/detail/BIM-274479
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 148
Record ID
BIM-274479