Experimental study for evaluation of antimicrobial activity of the aqueous garlic extract in treatment of arthritis in rabbits

Abstract EN

The study was conducted to evaluate the ability of Aqueous Garlic Extract (AGE) for inhibition the growth of Salmonella typhimuriwn as a probable cause of arthritis in rabbit's in vitro and in vivo study.

Results revealed that AGE (contain 201.2ug / ml allicin) have excellent antibacterial activity against this strain at > 60 % concentration, while the concentration > 20 % showed moderate activity, M oreover concentration °f < 20 % show no effect in vitro.

The in vivo study was explained the infectious dose of Salmonella typhimurium that induce arthritis in experimental animals was > lxlO5 C.F.U / ml when injected intrarticularly.

Garlic extract was administrated to treat experimental induced arthritis for 5 days by using different doses subcutaneously.

It has been shown that a dose rate of l00 mg / kg B.W S.C was more effective and has no adverse effects.

Some bacteriology, serology and hematological tests were used as indicators to confirm infection and evaluation of treatment in rabbits.