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Biological treatment failure in adult rheumatoid arthritis, why? what is next?
Author
Source
Egyptian Rheumatology and Rehabilitation
Issue
Vol. 33, Issue 4 (31 Oct. 2006), pp.453-466, 14 p.
Publisher
The Egyptian Society for Rheumatology and Rehabilitation
Publication Date
2006-10-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Objectives : to assess duration of treatment with Infliximab / Etanercept in a cohort of our RA patients and find out reasons for discontinuation of Infliximab / Etanercept in this cohort.
To identify the nature and frequency of the adverse reaction resulting in Infliximab / Etanercept discontinuation.
To identify if possible factors associated with failure of therapy.
To find out an alternatives to those who failed Infliximab / Etanercept treatment.
Subjects: Patients who were identified in our data base as having commenced and subsequently ceased Infliximab or / and Etanercept were included in our study.
Twenty Patients failed the biological treatment (16 women, 4 men ; mean age 54.5 years with a range from 21 to 74 years) has been included.
Conclusion : Anti-TNF medication should be more targeted in administration and withdrawal.
Patients who fail to respond to one TNF-alpha antagonist can respond to the other antagonist.
Furthermore, there appears to be no contraindication to using one TNF-alpha antagonist for patients who have developed hypersensitivity reactions to the other.
The side-effects observed in our study were generally mild and did not necessarily recur with the use of the second antagonist.
Further studies are needed to find out an alternative to DAS such as SDAI (simplified disease activity index).
American Psychological Association (APA)
al-Husayn, Azzah Husayn. 2006. Biological treatment failure in adult rheumatoid arthritis, why? what is next?. Egyptian Rheumatology and Rehabilitation،Vol. 33, no. 4, pp.453-466.
https://search.emarefa.net/detail/BIM-27460
Modern Language Association (MLA)
al-Husayn, Azzah Husayn. Biological treatment failure in adult rheumatoid arthritis, why? what is next?. Egyptian Rheumatology and Rehabilitation Vol. 33, no. 4 (Oct. 2006), pp.453-466.
https://search.emarefa.net/detail/BIM-27460
American Medical Association (AMA)
al-Husayn, Azzah Husayn. Biological treatment failure in adult rheumatoid arthritis, why? what is next?. Egyptian Rheumatology and Rehabilitation. 2006. Vol. 33, no. 4, pp.453-466.
https://search.emarefa.net/detail/BIM-27460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 465-466
Record ID
BIM-27460