Design and synthesis of a series of 3-aminobenzenesulfonamide derivatives and their screening for antimicrobial and cytotoxic activity
Other Title(s)
تصميم و تشييد مشتقات 3-أمينوبنزين سلفون أميد ومسح فعاليتها ضد الميكروبات و سميتها للخلية
Joint Authors
Qandil, Amjad Muhammad
Hassan, Muhammad Abd al-Hafiz
al-Juaydi, Bilal Ali
Source
Jordan Journal of Pharmaceutical Sciences
Issue
Vol. 1, Issue 1 (31 Jan. 2008), pp.41-54, 14 p.
Publisher
University of Jordan Deanship of Academic Research (DAR)
Publication Date
2008-01-31
Country of Publication
Jordan
No. of Pages
14
Main Subjects
Topics
Abstract AR
تم تصميم و تشييد مجموعة من مشتقات 3-أمينوبنزين سلفون أميد فيها تشعب على النيتروجين يحتوي على مجموعة اليوريا أو الثيويوريا أو أمين حلقي، و من ثم فحص فعاليتها ضد البكتيريا و ضد الكانديدا و مدى سميتها للخلية.
و قد كانت للمركبات المصنعة فعالية ضئيلة ضد البكتريا، و لكن أظهر كثير منها فعالية جيدة ضد الكانديدا، خاصة المركبات (2a, 2d, 2e, 3a, 3d, 4b, 4c, 4d, 4j, 4k, 4l and 4m)التي كان التركيز الأدنى القاتل لها بين 16 و 64 ميكروغرام / مل، و قد كانت لمشتقات اليوريا و الثيويوريا جميعها 3a-d 2 وa-f المركبات سمية عالية ضد يرقات القريدس.
Abstract EN
A series of 3-aminobenzenesulfonamide derivatives with a 3-N-substituted side chains that contain ureas, thioureas or cyclic amines was designed, synthesized and assayed for antibacterial, anti-candidal and cytotoxic activity.
The synthesized compounds exhibited minimal antibacterial activity but showed good anti-candidal activity, especially compounds 2a, 2d, 2e, 3a, 3d, 4b, 4c, 4d, 4j, 4k, 4l and 4m with MIC values ranging from 16-64 μg/mL.
The thiourea and urea (compounds 2a-f and 3a-d), but not the cyclic amine derivatives (compounds 4a-m), exhibited significant cytotoxic activity against brine shrimp.
American Psychological Association (APA)
Qandil, Amjad Muhammad& Hassan, Muhammad Abd al-Hafiz& al-Juaydi, Bilal Ali. 2008. Design and synthesis of a series of 3-aminobenzenesulfonamide derivatives and their screening for antimicrobial and cytotoxic activity. Jordan Journal of Pharmaceutical Sciences،Vol. 1, no. 1, pp.41-54.
https://search.emarefa.net/detail/BIM-274677
Modern Language Association (MLA)
al-Juaydi, Bilal Ali…[et al.]. Design and synthesis of a series of 3-aminobenzenesulfonamide derivatives and their screening for antimicrobial and cytotoxic activity. Jordan Journal of Pharmaceutical Sciences Vol. 1, no. 1 (Jan. 2008), pp.41-54.
https://search.emarefa.net/detail/BIM-274677
American Medical Association (AMA)
Qandil, Amjad Muhammad& Hassan, Muhammad Abd al-Hafiz& al-Juaydi, Bilal Ali. Design and synthesis of a series of 3-aminobenzenesulfonamide derivatives and their screening for antimicrobial and cytotoxic activity. Jordan Journal of Pharmaceutical Sciences. 2008. Vol. 1, no. 1, pp.41-54.
https://search.emarefa.net/detail/BIM-274677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 53
Record ID
BIM-274677
