Synthesis of some 1, 2, 4-triazolyl-1, 2, 3-triazole derivatives : 1, 3-dipolar cycloaddition reaction

Abstract EN

The reaction of 1-substituted benzyl-1H-1, 2, 3-triazole-4-carbohydrazides 2a-h with equimolar amounts of isothiocynate produces 1-(1-substituted benzyl-1H-1,2,3-triazole-4- carbonyl)-N-phenyl drazinecar bothioamide 3a-h.

Treatment of 3a-h with sodium hydroxide afforded 5-(1-substituted benzyl-1H-1, 2, 3-triazol-4-yl)-4-phenyl-4H-1, 2, 4-triazole-3-thiol 4a-h.

Nucleophlic addition of the corresponding sodium salts of 4a-h to alkyl halide (methyl iodide or benzyl bromide) affords the 1-substituted benzyl-4-(5-(alkylthio)-4-phenyl-4H-1, 2, 4-triazol-3-yl-1) H-1,2,3-triazole 5a-h and 6a-h.