Synthesis and biological evaluation of some new thienopyridine and thienopyrimidine derivatives

Abstract EN

Reactions of 3-amino-2-(4-bromobenzoyl)-4-cyano-5-phenyl-aminothiophene (3a) or 2- acetyl-3-amino-4-cyano-5-phenylamino-thiophene (3b) with a variety of active methylene compounds, such as ethyl cyan acetate, ethyl acetoacetate, ethyl benzoyl acetate and diethyl malonate, yielded the corresponding thieno [3,2-b]pyridine-2-one derivatives (4a, b-7a,b).

Also the reaction of (3a) or (3b) with form amide and formic acid, afforded the corresponding thieno [3, 2-d] pyrimidine derivatives (8a, b).

While the reaction of compound (3a) with phenyl isothiocyanate, yielded thieno [3, 2-b] pyrimidin-2-thione derivative (9).