Spectroscopic and conductometric investigation of the interaction of azithromycin with iron (II) ion
Joint Authors
al-Rjoob, Abd al-Wahhab
al-Mustafa, Jamil
Taha, Ziyad Iyad
Abous, Mwafaq
Source
Issue
Vol. 3, Issue 2 (30 Jun. 2008), pp.199-209, 11 p.
Publisher
Yarmouk University Deanship of Research and Graduate Studies
Publication Date
2008-06-30
Country of Publication
Jordan
No. of Pages
11
Main Subjects
Topics
Abstract EN
The interaction of the antibiotic azithromycin with ferrous sulfate and ferrous perchlorate in methanol has been investigated by spectroscopic and conduct metric methods under equilibrium conditions.
The interaction of azithromycin with both salts has been found to form one complex with metal to ligand composition of 1 : 1.
The value of log Kf calculated from the absorption spectra for FeSO4-azithromycin complex at 25°C was 5.16 ± 0.07 (Kf = 1.4 x 105 M-1).
The value of log Kf for Fe (ClO4)2-azithromycin complex calculated from the conductivity measurements at 25°C was 5.20 ± 0.08 (Kf = 1.6 x 105 M-1).
The enthalpy and entropy of complication were determined from the temperature dependence of the complication constants.
The ΔHº and ΔSº were 103.8 kJ / mol and 486.9 J / mol.K, respectively.
The calculated molar conductivity of the Fe (ClO4)2-azithromycin complex at 25°C was 99.7 S cm2 mol-1.
This high molar conductivity has been considered indicative of the formation of a charged complex formed from the coordination of the neutral azithromycin ligand to the iron (II) ion without being accompanied by loss of protons.
American Psychological Association (APA)
al-Rjoob, Abd al-Wahhab& al-Mustafa, Jamil& Taha, Ziyad Iyad& Abous, Mwafaq. 2008. Spectroscopic and conductometric investigation of the interaction of azithromycin with iron (II) ion. Jordan Journal of Chemistry،Vol. 3, no. 2, pp.199-209.
https://search.emarefa.net/detail/BIM-275352
Modern Language Association (MLA)
al-Rjoob, Abd al-Wahhab…[et al.]. Spectroscopic and conductometric investigation of the interaction of azithromycin with iron (II) ion. Jordan Journal of Chemistry Vol. 3, no. 2 (Jun. 2008), pp.199-209.
https://search.emarefa.net/detail/BIM-275352
American Medical Association (AMA)
al-Rjoob, Abd al-Wahhab& al-Mustafa, Jamil& Taha, Ziyad Iyad& Abous, Mwafaq. Spectroscopic and conductometric investigation of the interaction of azithromycin with iron (II) ion. Jordan Journal of Chemistry. 2008. Vol. 3, no. 2, pp.199-209.
https://search.emarefa.net/detail/BIM-275352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 209
Record ID
BIM-275352