Assessment of immunoglobulin’s in the serum of children with shigellosis

Abstract EN

During a period of nine months from January 2006 to September 2006.

Sixty–Two cases of shigellosis were collected at Nassiria Pediatric hospital (Age ranged from one day to five years).

A total of 317 cases suffering from bloody diarrhea, out of 317 stool samples, 62 bacterial isolates were obtained represent 19.5 % from all cases of diarrhea, the isolates identified were, Shigella dysenteriae, Shigella sonnei, Shigella boydii, and Shigella flexneri.

The percentage of each are, 22(35.4 %), 19(30.6 %), 13(20.9 %), 8(12.9 %) respectively.

Shigellosis was predominant in those below one year of age (32.2 %).

The concentration of total protein level in the serum of children with shigellosis was normal in all age groups, while albumin was low, alpha 1–globulin concentration was high, alpha 2–globulin increased slightly with advancing age, beta–globulin concentration in serum of children was normal, gamma globulin concentration was slightly elevated in most age groups.

Forty–Seven children (75.8 %) are found to have high level of lmmunoglobulins concentration while fifteen children (24.2 %) have low levels of lmmunoglobulin concentration.

They are classified as follows : 11.2 % have IgA deficiency, 5.1 % have IgM deficiency and 4.8 % have IgG deficiency.

These results revealed that Ig deficiency is associated with shigellosis.