Antibacterial activity of some antineoplastic drugs against.staphylococcus aureus isolated for UTI

Abstract EN

Antibacterial activity of methotrexate, 6-mercaptopurine, thioguanine and 5-fluorouracil against twenty isolates of Staphylococcus aurous isolated from UTI in children were studied .Ten of these isolates were isolated from urine samples of children suffering from leukemia in addition to UTI and showed completely resistance to all of these drugs, comparing with the other isolates were showed sensitivity to the drugs above except methotrexate.

A phenomenon synergism between methotrexate and each of 5-fluorouracil and 6-mercaptopurine to inhibit the isolates from non-leukemic children were detected .Synergism also occurred between each of methotrexate, 6-mercaptopurine and 5-fluorouracil and the antibiotics : ciprofloxacin, amoxicillin, co-trimoxazole and Ceftazidime to inhibit these isolates.

Hemolysin production by Staph, aurous was inhibited in presence of methotrexate in the culture.