Oxidative cyclization of arylidene carboxyhydrazides : synthesis of substituted hydroxydiphenylmethyl-1, 3, 4-oxadiazoles

Abstract EN

The synthesis and characterization of a series of 5-aryl-1, 3, 4-oxadiazol-2-yldiphenylmethanols (4) was achieved by oxidative cyclization of N'-(3-aryl) methylene]-2-hydroxy-2-, 2 diphenylacetohydrazides (3) with lead (IV) acetate.

The S-{5- [hydroxyl- (diphenyl) methyl]-1, 3, 4 oxadiazol-2-yl}-aryl carbothioates (7) were prepared by the reaction of (5-mercapto-1, 3, 4-oxadiazol-2-yl) (diphenyl) methanol (5) with the respective acid chlorides.