A study of the effect of deprotonation process on the biological activity of some purine and pyrimidine derivatives

Abstract EN

This study has been included the synthesis of four new compounds by allylation and tosylation of 2, 4-dioxopurine and 5- amino-2, 4, 6- trioxopyrimidine .

The characterization of the products was done by elemental analysis (C, H, N % ) and spectroscopic methods, 1H- NMR, UV and IR in solid state indicates that the deprotonation process has occurred at N – H position of the pyrimidine and purine compounds.

The study of the biological activity of the prepared compounds is represented by the determination of their inhibition diameters and minimum inhibitory concentrations.

This study shows that the biological activity of the products is not ascribed to the type of substituent group attached to the hetro-nitrogen atom instead of the proton ,but it is ascribed to the deprotonation process itself.