فنيلة المضاد الحيوي اوكسي تترا سايكلين (تيرا مايسين )‎ و دراسة فعالية الناتج المتوقعة المضادة للبكتريا

Abstract EN

In this study chemical modification has been achieved for terramycine (oxytetracycline), antibiotic by replacement the protons of amide group by vinyl group , through the treatment of terramycine with vinyl acetate and potassium carbonate in the presence of dimethyl formamide ( DMF) as solvent.

It was noted that the product has substituted vinyl groups , indicated by physical measurements , and spectroscopic identifications ( UV and IR spectra).

Also the study was determined the antibacterial activity of the prepared derivative represented by inhibition diameters , minimum inhibitory concentrations and cytotoxicity.