Amyloid goiter : rerort of a case and review of iterature

Abstract EN

Amyloid goiter is an exceedingly rare pathological condition associated with a clinically apparent enlargement of the thyroid gland due to massive amyloid deposition.

It has to be distinguished from other causes of goiter and from neoplasm.

It occurs either as a localized phenomenon, usually associated with medullary thyroid carcinoma, or occurs in association with systemic amyloidosis, both primary and secondary.

The authors report a case of amyloid goiter that occurs in sixteen years old thyroid female patient who turned to have familial Mediterranean fever.

She presented with a progressively enlarged thyroid gland associated with upper airway obstructive symptoms.

Histological examination showed extensive amyloid deposition.

Later evaluation revealed amyloid deposition in other part of the body.

In conclusion, although rare, a diagnosis of amyloid goiter should be suspected in a patient with known underlying predisposing factors who present with a rapidly growing diffuse goiter associated with thyroid state.

It can present as the first manifestation of systemic amyloidosis.

Histologic examination is necessary to establish the diagnosis and to rule out neoplasm.