Use of BCG vaccine for enhancement the immune response of sheep to rev. 1 vaccination

Abstract EN

This study was conducted to evaluate the protective effect of Brucella melitensis Rev.1 and the use of BCG vaccine as immunostimulant by subcutaneous injection in Guinea pigs.

Lab.

Animals were divided into 8 groups: Combined Rev.1 and BCG vaccines injected in the 1st group and both vaccines were injected simultaneously in the 2nd group.

Three groups sensitized with BCG vaccine then injected with Rev.1 vaccine one, two and three weeks intervals respectively.

The other Two groups were injected with BCG and Rev.1 vaccine individually.

The last one was unvaccinated control.

All injected animals showed resistance to infection with 16 M strain (90 %, 80 %, 60, 80 %, 70 %, 0 % and 70 % respectively).

Thus animals vaccinated with bivalent Rev.1 and BCG vaccines (in one shot) showed the best protective level to infection.