Protective role of phoenix dactylifera-l extract (dates)‎ and ascorbic acid in thioacetamide induced hepatotoxicity in rats

Abstract EN

The ameliorative activity of aqueous extract of the flesh of dates (Phoenix dactyl feral L.) and Ascorbic acid on thioacetamide-induced hepatotoxicity was studied in rats.

Sixty male rats were divided into six equal groups.

Two groups were served as controls, one treated with thioacetamide and the other received distilled water.

Two groups received extract of flesh phoenix dactylifera and intraperitoneal (IP) with thioacetamide (400 mg / kg b.

wt.) either before or after administration of flesh extract.

Two groups received ascorbic acid and intraperitoneal (IP) thioacetamide (400 mg / kg b.

wt.) either before or after administration of ascorbic acid.

Liver damage was assessed by estimation of plasma concentration of bilirubin and hepatic enzymatic activities of aspirate aminotransferase, alanine aminotransferase, lactate dehydrogenase, Y glutamyl transferase, alkaline phosphatase, serum alpha fetoprotein and serum total testosterone.

Treatment with aqueous extract of date flesh or by ascorbic acid significantly reduced thioacetamide-induced elevation in plasma bilirubin concentration and enzymes.

This study suggests that thioacetamide-induced liver damage in rats can be ameliorated by treatment with dates flesh and ascorbic acid extracts.