Relationship between coxsackie B-4 virus infection and type-1 diabetes in children
Other Title(s)
العلاقة بين عدوى كوكزاكي ب4 و مرض السكر من النوع الأول في الأطفال
Joint Authors
Bdari, Muhammad Sad
Rashwan, Nabilah Muhammad Mahmud
Ahmad, Ahmad Sadiq
Shoreit, Asmmaa H. A.
Uthman, Amjad Ahmad Izzat
Ajban, Mikhail Nazmi
Source
Issue
Vol. 33, Issue 1 (31 Jan. 2009), pp.9-16, 8 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2009-01-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract AR
نهدف في هذا البحث الى ايجاد معدل حدوث الاصابة بفيروس الكوكزاكي ب 4و المسبب لمرض السكر من النوع الاول في الاطفال من مستشفى طب الاطفال بجامعة اسيوط .
استخدمنا مختلف الطرق للتشخيص ومنها زرع الانسجه وتفاعلات السلسلة المتبلمرة .
ونتج البحث عن انه 7,54 % من الحالات مصابة بالفيروس .
يعتقد ان النوع الاول من مرض السكر ينتج عن التدمير الذاتي المناعة لخلايا بيتا بالبنكرياس و يحدث للأشخاص المستعدين وراثيا لحدوث ذلك والذي يبتدء او يعجل حدوثه بالعوامل البيئية .
واحد هذه العوامل هي العدوى بالفيروسات المعوية .
وعزل الفيروس وتعرف عليه وكان فيروس كوكزاكي ب .
4 ووجد ان الفيروس المعزول كان قادرا على احداث العدوى خارجيا في الكائنات الحية متعددة الاعضاء وغير مصابة بالسكر من النوع الاول وادى ايضا الى تدمير خلايا بيتا و قلة افراز الانسولين.
Abstract EN
Type-1 diabetes mellitus is believed to result from the selective autoimmune destruction of pancreatic islet cells, occurring in genetically predisposed subjects, and possibly triggered or accelerated by environmental agents.
One of the environmental risk factors identified by several independent studies is represented by enter viral infection.
The virus was isolated from infected islets of patients, sequenced, and identified as a Coxsackie B4.
In addition, isolated virus was able to in vitro infect cells from non-diabetic multi-organ donors, causing cell dysfunction characterized by impaired glucose stimulated insulin release.
We tried to detect the incidence of virally caused type one Diabetes Mellitus with the Coxsackie B4 among cases in Pediatric Department in Assiut University Hospitals.
Fifty three cases with recent onset diabetes and 25 matched controls were recruited for the study.
We used different techniques to find our targets, including Tissue Culture and PCR.
The search yields positively for CVB4 in 54.7 % of cases and 4 % of controls.
Conclusion: coxsackie B4 may be one of the most common causes of type I Diabetes Mellitus and should be considered in treating of these patients.
American Psychological Association (APA)
Rashwan, Nabilah Muhammad Mahmud& Ahmad, Ahmad Sadiq& Shoreit, Asmmaa H. A.& Bdari, Muhammad Sad& Uthman, Amjad Ahmad Izzat& Ajban, Mikhail Nazmi. 2009. Relationship between coxsackie B-4 virus infection and type-1 diabetes in children. Assiut Medical Journal،Vol. 33, no. 1, pp.9-16.
https://search.emarefa.net/detail/BIM-27865
Modern Language Association (MLA)
Rashwan, Nabilah Muhammad Mahmud…[et al.]. Relationship between coxsackie B-4 virus infection and type-1 diabetes in children. Assiut Medical Journal Vol. 33, no. 1 (Jan. 2009), pp.9-16.
https://search.emarefa.net/detail/BIM-27865
American Medical Association (AMA)
Rashwan, Nabilah Muhammad Mahmud& Ahmad, Ahmad Sadiq& Shoreit, Asmmaa H. A.& Bdari, Muhammad Sad& Uthman, Amjad Ahmad Izzat& Ajban, Mikhail Nazmi. Relationship between coxsackie B-4 virus infection and type-1 diabetes in children. Assiut Medical Journal. 2009. Vol. 33, no. 1, pp.9-16.
https://search.emarefa.net/detail/BIM-27865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 14-15
Record ID
BIM-27865