Effect of some antibiotics therapy on the efficacy of S-19 vaccine

Abstract EN

In this study, six groups, each of 15 guinea pigs vaccinated with Brucella abortus strain 19 vaccine (S-19 vaccine).

Each one of 5 groups were administered with different broad spectrum antibiotics (one antibiotic for each group) by in a dose of 25 mg / kg of body weight daily started from the second week of vaccination for one week, these antibiotics includes thiophenicol, oxycycline, gentamicin, amikin and ceftazidime respectively.

The sixth group was left as a vaccinated control group.

Eight weeks post-vaccination, each guinea pigs was experimentally infected with 5 x 103 viable count of virulent Brucella abortus strain 2308 (challenge or potency test).

It was found that the antibiotics therapy affect on S-19 vaccine efficacy with different degrees.

As the immune response of S-19 vaccine was decreased when the animals administered with thiophenicol, oxycycline and gentamicin, while the amikin and ceftazidime has less effect on the immune response of S-19 vaccine.