Comparative studies on two anesthetic cocktails in dogs

Abstract EN

This study was performed to compare the anesthetic effects of two cocktails injected intravenously in two groups of mongrel dogs, at a dose rate of (15 mg ketamine Hcl, 1.5 mg xylazine Hcl, 0.05 mg atropine sulphate) in addition to 0.75 mg acetylpromazine in the first group or 0.75 mg nalbuphine Hcl / Kg of body weights in the second group.

The vital signs, protective reflexes, mean of induction, surgical anesthesia, analgesia, total sleep, recovery and total sedation times were evaluated.

Blood chemistry were determined 10 minute before administration and at 10, 20 and 40 minutes after administration of both cocktails.

Dogs under both treatments were attained very fast, smooth induction, excitement free and full anesthetic status developed a sufficient deep analgesia and muscle relaxation.

No significant changes in vital signs were noticed but hypothermia at 45 and 30 minutes after first and second cocktail administration respectively.

Sharp decrease in respiratory rate (8.5 ± 1.500) breath / minute at 5 minute post administration of the second cocktail.

The mean of induction times were (0.325 ±.0.131 and 0.525 ± .0.149), surgical anesthesia time (39.5 ± .3.06 and 35.50 ± .3.796), duration of analgesia (24.50 ± .2.63 and 33.750 ± .4.26) ,total sleep time (45.50 ± .3.095 and 42.00 ± .3.391),recovery times (53.25 ± .4.441 and 50.00 ± .4.564) and duration of sedation (155.00 ± .13.228 and 115.00 ± .17.078)after first and second cocktail administration respectively.

There were no significant changes in biochemical analysis in first cocktail but there was a significant increase in potassium (K) in the second cocktail at 10 and 20 minutes.

Recovery from the effect of both cocktails was very smooth and struggle free.

It was concluded that addition of acetylpro-mazine or nalbuphine Hcl to the ketamine / xylazine combina-tion produces short and smooth induction, longer duration of anesthesia, analgesia, total sleep time and sedation.

Those cocktails provide postoperative analgesia and overcome the cardiopulmonary adverse effects produced by ketamine and xylazine combination only.