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Mycophenolate sodium increases cyclosporine blood levels in renal transplant recipients
Joint Authors
Tahiri, Said
Pourfarziani, Vahid
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 20, Issue 6 (31 Dec. 2009), pp.991-994, 4 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2009-12-31
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
Abstract EN
Cyclosporine is an immunosuppressive agent that displays a broad intra- and interindividual pharmacokinetic variability.
To evaluate the factors, which significantly influence cyclosporine blood levels in our renal transplant recipients, we studied 611 consecutive patients transplanted from living donors in Baqiyatallah hospital, Tehran, Iran from 1984 to 2005.
The patients were divided into two groups : Group I included patients treated with mycophenolate sodium (MS) as an adjunctive immunosuppressive agent and Group II treated with azathioprine (AZA) as an adjunctive agent.
Measurements of cyclosporine blood tough levels (C0) were performed 12 hours after the morning dose (just before the night dose).
The mean age of the study population at time of transplantation was 38.7 ± 13.7 years and males formed 67 % of it.
Univariate analysis and multivariable linear regression model showed that older age at transplantation, treatment with MS, and time interval from time of transplantation were significantly related with higher C0 levels.
We conclude that there is an interaction of immunosuppressive agents in renal transplant patients with higher cyclosporine levels in the recipients of MS.
American Psychological Association (APA)
Pourfarziani, Vahid& Tahiri, Said. 2009. Mycophenolate sodium increases cyclosporine blood levels in renal transplant recipients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 20, no. 6, pp.991-994.
https://search.emarefa.net/detail/BIM-279675
Modern Language Association (MLA)
Pourfarziani, Vahid& Tahiri, Said. Mycophenolate sodium increases cyclosporine blood levels in renal transplant recipients. Saudi Journal of Kidney Diseases and Transplantation Vol. 20, no. 6 (Dec. 2009), pp.991-994.
https://search.emarefa.net/detail/BIM-279675
American Medical Association (AMA)
Pourfarziani, Vahid& Tahiri, Said. Mycophenolate sodium increases cyclosporine blood levels in renal transplant recipients. Saudi Journal of Kidney Diseases and Transplantation. 2009. Vol. 20, no. 6, pp.991-994.
https://search.emarefa.net/detail/BIM-279675
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 993-994
Record ID
BIM-279675