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Is short term outcome of Iranian renal transplant recipients affected by mean first 6 months C2 level?
Joint Authors
Lankarani, Maryam Mughani
Einollahi, Behzad
Assari, Shervin
Panahi, Yunus
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 20, Issue 6 (31 Dec. 2009), pp.1101-1104, 4 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2009-12-31
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
- Patients
- Physiological effects
- Kidneys
- Diseases
- Iran
- Organ transplantation
- Complications(Medicine)
- Immunosuppressive agents
Abstract EN
International Consensus Conference (ICC) has suggested that the whole blood level of Cyclosporine (CsA) be kept strictly at a certain level.
However, it is not well understood whether failing to maintain these levels will affect the short term outcome in different patient populations or not.
We aimed to assess if the short term outcome of Iranian renal transplant recipients will be affected by first 6 months C2 level.
In a retrospective cohort, 265 consecutive kidney transplant recipients were categorized as group with mean C2 lower than recommended range (mean C2 levels in the first 6 month after transplantation lower than the recommended ranges ; n = 213) and group with mean C2 within recommended range (mean C2 levels in the first 6 month after transplantation within the recommended range ; n = 52).
All recipients were negative for panel reactive antibody, and had received their first (living unrelated) kidney transplantation in Baqiyatallah hospital, between 2002 and 2003.
The groups were similar in characteristics and 6 months, 1, 2, and 3 years patient and graft survival rates were considered as outcome.
No significant difference was observed in patient and graft survival rates between the two groups (P > 0.05).
The patient survival rate in group with mean C2 lower than recommended range and group with mean C2 within recommended range were: 6 months : 98 % vs.
98, 1 year : 97 % vs.
98 %, 2 years : 97 % vs.
98 % and 3 years : 97 % vs.
98 %.
The graft survival rate in the above groups were as follows : 6 months: 93 % vs.
91 %, 1 year : 92 % vs.
91 %, 2 years : 92 % vs.
77 % and 3 years : 89 % vs.
69 %, respectively.
The result of our study showed that lower mean C2 levels was not necessarily accompanied with a worse short term outcome in our patients.
This finding suggests that the optimal level of C2 may be different in ethnic populations.
American Psychological Association (APA)
Assari, Shervin& Lankarani, Maryam Mughani& Panahi, Yunus& Einollahi, Behzad. 2009. Is short term outcome of Iranian renal transplant recipients affected by mean first 6 months C2 level?. Saudi Journal of Kidney Diseases and Transplantation،Vol. 20, no. 6, pp.1101-1104.
https://search.emarefa.net/detail/BIM-279808
Modern Language Association (MLA)
Assari, Shervin…[et al.]. Is short term outcome of Iranian renal transplant recipients affected by mean first 6 months C2 level?. Saudi Journal of Kidney Diseases and Transplantation Vol. 20, no. 6 (Dec. 2009), pp.1101-1104.
https://search.emarefa.net/detail/BIM-279808
American Medical Association (AMA)
Assari, Shervin& Lankarani, Maryam Mughani& Panahi, Yunus& Einollahi, Behzad. Is short term outcome of Iranian renal transplant recipients affected by mean first 6 months C2 level?. Saudi Journal of Kidney Diseases and Transplantation. 2009. Vol. 20, no. 6, pp.1101-1104.
https://search.emarefa.net/detail/BIM-279808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1103-1104
Record ID
BIM-279808