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Comparison of two commercial assays and microscopy with PCR for diagnosis of malaria
Joint Authors
Ageely, H. M.
Haybah, A. A.
Dawud, H. A.
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 38, Issue 2 (31 Aug. 2008), pp.329-338, 10 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2008-08-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Topics
Abstract EN
This study compared conventional PCR with microscopy and 2 rapid detection methods, the pLDH which detected lactic dehydrogenase enzyme produced by actively metabolizing organisms and the malaria antibody tests.
The sensitivity of PCR was 1 parasite / μl, i.e.: 50 times more sensitive than microscopy.
When PCR was compared with microscopy, the sensitivity and specificity were 90 % and 100 % respectively.
The sensitivity recorded was pLDH test in comparison to PCR (95 %).
The malaria antibody test recorded the least sensitivity (68 %) PCR proved as the gold standard for evaluation of applied tests and the newly introduced ones.
In absence of an expert microscopes, the pLDH test could substitute for microscopy.
The test proved valuable to assess clinical cure, and predict drug resistance.
Its advantage over microscopy was the ability to diagnose infection with low parasitic patients.
Antibody rapid tests might be not valuable in acute cases, but still accepted as a tool in epidemiological studies and in screening patients in blood banks in malaria endemic areas.
American Psychological Association (APA)
Dawud, H. A.& Ageely, H. M.& Haybah, A. A.. 2008. Comparison of two commercial assays and microscopy with PCR for diagnosis of malaria. Journal of the Egyptian Society of Parasitology،Vol. 38, no. 2, pp.329-338.
https://search.emarefa.net/detail/BIM-279832
Modern Language Association (MLA)
Dawud, H. A.…[et al.]. Comparison of two commercial assays and microscopy with PCR for diagnosis of malaria. Journal of the Egyptian Society of Parasitology Vol. 38, no. 2 (Aug. 2008), pp.329-338.
https://search.emarefa.net/detail/BIM-279832
American Medical Association (AMA)
Dawud, H. A.& Ageely, H. M.& Haybah, A. A.. Comparison of two commercial assays and microscopy with PCR for diagnosis of malaria. Journal of the Egyptian Society of Parasitology. 2008. Vol. 38, no. 2, pp.329-338.
https://search.emarefa.net/detail/BIM-279832
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 336-338
Record ID
BIM-279832