Anemia, interleukin-10, tumor necrosis factor alpha, and erythropoietin levels in children with acute, complicated and uncomplicated malignant malaria in Jazan, Saudi Arabia
Joint Authors
Ageely, H. M.
Haybah, A. A.
Dawud, H. A.
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 38, Issue 2 (31 Aug. 2008), pp.359-370, 12 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2008-08-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Topics
Abstract EN
To gain insight into potential relationships between tumor necrosis factor alpha (TNF-α), interleukin 10 (IL-10), erythropoietin (EPO), and anemia in acute malaria, 90 children 3 to 11 years with acute mal-aria were studied.
According to parasitemia and hemoglobin levels, they were divided into 3 groups : G1 (mild) : asexual low-density Plasmodium falciparum parasitemia < 8000 parasites / ul and hemoglobin levels >8g / dl.
G2 (high-density uncomplicated) : asexual high-density parasitemia (>8000 parasites / ul, with hemoglobin levels >8 g/dl.
G3 (anemia): with severe malaria symptoms and parasitemia with anemia (hemoglobin levels <8 g / dl).
Hospital controls included 10 children with matching age group who required inpatient management but had no malaria parasitemia.
Good marrow response was in G1 and G2 showed by elevation of serum EPO and soluble transferring receptors (sTfR) and increased red cell distribution width (RDW).
In G3, bone marrow suppression was in spite of increased EPO level in response to anemia.
TNF-α level was significantly higher G2 and G3 (P.05).
IL-10 levels in G1 were significantly higher than in hospital control group (P<0.05).
The highest level of IL-10 was in G2.
The mean IL-10 to TNF- α ratio in G2 (4.64) was significantly higher (P < .005) than in G3 (mean ratio, 1.77).
American Psychological Association (APA)
Ageely, H. M.& Dawud, H. A.& Haybah, A. A.. 2008. Anemia, interleukin-10, tumor necrosis factor alpha, and erythropoietin levels in children with acute, complicated and uncomplicated malignant malaria in Jazan, Saudi Arabia. Journal of the Egyptian Society of Parasitology،Vol. 38, no. 2, pp.359-370.
https://search.emarefa.net/detail/BIM-279849
Modern Language Association (MLA)
Ageely, H. M.…[et al.]. Anemia, interleukin-10, tumor necrosis factor alpha, and erythropoietin levels in children with acute, complicated and uncomplicated malignant malaria in Jazan, Saudi Arabia. Journal of the Egyptian Society of Parasitology Vol. 38, no. 2 (Aug. 2008), pp.359-370.
https://search.emarefa.net/detail/BIM-279849
American Medical Association (AMA)
Ageely, H. M.& Dawud, H. A.& Haybah, A. A.. Anemia, interleukin-10, tumor necrosis factor alpha, and erythropoietin levels in children with acute, complicated and uncomplicated malignant malaria in Jazan, Saudi Arabia. Journal of the Egyptian Society of Parasitology. 2008. Vol. 38, no. 2, pp.359-370.
https://search.emarefa.net/detail/BIM-279849
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 367-370
Record ID
BIM-279849