Potential effect of curcuma longa extract on infectivity and pathogenicity of schistosoma mansoni cercariae
Joint Authors
Shoheib, Zaynab S.
Diyab, Futuh A.
Dar, Yasir D.
Kabbash, Amal M.
al-Nouby, Khulud A.
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 38, Issue 1 (30 Apr. 2008), pp.141-161, 21 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2008-04-30
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Topics
Abstract EN
Batch of freshly shed cercariae from infected laboratory bred Bio-mphalaria alexandrina were exposed to different sub-lethal concentrations of turmeric extract for an hour and divided into two groups.
The first one was to study the ultra-structural changes induced in them using scanning electron microscopy (SEM).
The second group was to study infectivity and pathogenicity of the exposed cercariae.
One hundred and fifty mice were divided into 5 groups : GI : Infected by nor-mal cercariae and served as controls ; GII, GIII, GIV and GV infected by cercariae exposed to 2.5, 5, 7.5 and 10 ppm, respectively.
Ten weeks post infection all animals were sacrificed and subjected to parasitological, histopathology and immunologic assays.
SEM showed cercariae exposed to 5ppm with minimal destruction of head spines and tail.
The degenerative changes were progressively severe by increasing extract concentration to reach complete destruction of both at 10 ppm.
Infectivity decreased with the increase in concentration to reach high-est significance at 10 ppm.
Pathogenicity or mean number of egg deposited, mean diameter of liver granulomas and level of IL-10 gene ex-pression significantly decreased in Gs IVand V.
American Psychological Association (APA)
Shoheib, Zaynab S.& al-Nouby, Khulud A.& Diyab, Futuh A.& Dar, Yasir D.& Kabbash, Amal M.. 2008. Potential effect of curcuma longa extract on infectivity and pathogenicity of schistosoma mansoni cercariae. Journal of the Egyptian Society of Parasitology،Vol. 38, no. 1, pp.141-161.
https://search.emarefa.net/detail/BIM-280261
Modern Language Association (MLA)
al-Nouby, Khulud A.…[et al.]. Potential effect of curcuma longa extract on infectivity and pathogenicity of schistosoma mansoni cercariae. Journal of the Egyptian Society of Parasitology Vol. 38, no. 1 (Apr. 2008), pp.141-161.
https://search.emarefa.net/detail/BIM-280261
American Medical Association (AMA)
Shoheib, Zaynab S.& al-Nouby, Khulud A.& Diyab, Futuh A.& Dar, Yasir D.& Kabbash, Amal M.. Potential effect of curcuma longa extract on infectivity and pathogenicity of schistosoma mansoni cercariae. Journal of the Egyptian Society of Parasitology. 2008. Vol. 38, no. 1, pp.141-161.
https://search.emarefa.net/detail/BIM-280261
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 159-161
Record ID
BIM-280261